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TranscriptomicsTranscription profiling of human Low Malignancy Potential (LMP) and serous tumours
Expression profile of 30 LMP tumours and 60 Serous tumours were compared to identify the biolgical pathways specific to these groups. Genotyping was done to identify the mutations potentially causing these phenotypes Experiment Overall Design: Expression profile of 30 LMP tumours and 60 Invasive sro...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-12172 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of OVCAR-3 and CDK2 resistant sublines
Cyclin E1 (CCNE1) is amplified in various tumor types including high-grade serous ovarian cancer where it is associated with poor clinical outcome. We have demonstrate that suppression of the Cyclin E1 partner kinase, CDK2, induces apoptosis in a CCNE1 amplicon-dependent manner. Little is known of m...
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-48919 | biostudies-arrayexpress
TranscriptomicsCopy number analysis of OVCAR-3 and CDK2 resistant sublines
Cyclin E1 (CCNE1) is amplified in various tumor types including high-grade serous ovarian cancer where it is associated with poor clinical outcome. We have demonstrate that suppression of the Cyclin E1 partner kinase, CDK2, induces apoptosis in a CCNE1 amplicon-dependent manner. Little is known of m...
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-48920 | biostudies-arrayexpress
UnknownMolecular correlates of platinum response in human high-grade serous ovarian cancer patient-derived xenografts.
Not available
S-EPMC4400120 | biostudies-literature
TranscriptomicsTranscription profiling of human 293T cells transfected with HIPK2 or an empty vector and exposed to either hypoxia or normoxia conditions
To determine the consequences of hypoxia-mediated HIPK2 clearance on gene expression, cells 293T were transfected with either the HIPK2 expression vector or the corresponding empty vector and then subjected to either hypoxia conditions (2% O2 for 6 h) or normoxia conditions. RNA total was extracted ...
ORGANISM(S): Homo sapiens 
2009-01-05 | E-MEXP-1896 | biostudies-arrayexpress
TranscriptomicsExpression data from exponentially proliferating ovarian cancer cell lines
We used microarrays to assess gene expression in proliferating ovarian cancer cell lines Ovarian cancer cell lines were plated and harvested when 50-80% confluent. RNA was extracted and hybridized on Affymetrix microarrays. At least 3 biological repeats were performed for each cell line.
ORGANISM(S): Homo sapiens 
2013-01-26 | E-GEOD-43765 | biostudies-arrayexpress
UnknownSelective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition.
Not available
S-EPMC5364079 | biostudies-literature
UnknownMutation of ERBB2 provides a novel alternative mechanism for the ubiquitous activation of RAS-MAPK in ovarian serous low malignant potential tumors.
Not available
S-EPMC6953412 | biostudies-literature
TranscriptomicsGene expression and copy number analysis of OVCAR-3 and CDK2 resistant sublines
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-48921 | biostudies-arrayexpress
TranscriptomicsGene expression profiling after RNA interference of CXCR4 in human ovarian cancer cell line IGROV-1.
In the past three years the role of inflammatory cytokines and chemokines in tumour promotion and progression has been intensively studied. The chemokine receptor CXCR4 and its ligand CXCL12 are commonly expressed in malignant cells from primary tumours, metastases and also in malignant cell lines. ...
ORGANISM(S): Homo sapiens 
2009-01-13 | E-GEOD-13763 | biostudies-arrayexpress
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