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The Crumbs complex is a regulator of epithelial polarity and is important for the formation of the apical domain. The Crumbs complex consists of the Crumbs protein, Pals1, and PATJ. In C. elegans, we identify MAGU-2 as an ortholog of Pals1. We find that MAGU-2 localizes apically in epithelial cells ...
ORGANISM(S): Caenorhabditis elegans 
2022-05-19 | PXD030122 | Pride
Animal germ cells employ small RNA-based mechanisms to recognize and silence DNA that invades their genome. One of these pathways is named the Piwi:piRNA pathway. Biogenesis of piRNAs is poorly understood. In C. elegans, the piRNA (21U-RNA)-binding Argonaute protein PRG-1 is the only known player ac...
ORGANISM(S): Caenorhabditis elegans 
Epithelial tubes are essential components of metazoan organ systems that control the flow of fluids and the exchange of materials between body compartments and the outside environment. The size and shape of the central lumen confer important characteristics to tubular organs and need to be carefully...
ORGANISM(S): Homo sapiens (Human) Caenorhabditis elegans 
2021-04-07 | PXD024387 | Pride
Tissue specific microarray data is obtained by generating a whole-organism extract and subsequent co-immune precipitation of mRNA with the poly-A binding protein FLAG::PAB-1 specifically expressed in body wall muscle cells (Roy et al. 2002). Different lines were compared: SV911 (control), SV912 (CY...
ORGANISM(S): Caenorhabditis elegans 
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