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TranscriptomicsRNA abundance in wild-type and rtt109 -/- Candida albicans, with and without peroxide stress
Candida albicans is a ubiquitous opportunistic pathogen that is the most prevalent cause of hospital-acquired fungal infections. In mammalian hosts, C. albicans is engulfed by phagocytes that attack the pathogen with DNA-damaging reactive oxygen species (ROS). Acetylation of histone H3 lysine 56 (H3...
ORGANISM(S): Candida albicans 
2010-05-16 | E-GEOD-18936 | biostudies-arrayexpress
TranscriptomicsAnalysis of gene deletion induced changes in the transcriptome of human macrophage-like cells
To study the effect of genes that interface inflammatory and metabolic signaling, CRISPR/Cas9 has been used to delete CD5L and RORA in THP-1 human monocytic cell line. Cells transduced with sgRNAs targeting Renilla luciferase gene were used as controls. Deletion and control lines were differentiated...
ORGANISM(S): Homo sapiens 
2018-12-17 | E-MTAB-7295 | biostudies-arrayexpress
GenomicsAmplicon sequencing data of sgRNA cassettes from pig CRISPR screening time course to identify essential genes in PK15 and IPEC-J2 cell lines
This study describes a genome-wide CRISPR-Cas9 knockout (GeCKO) screen performed in two porcine cell lines, PK15 and IPEC-J2. A custom-designed porcine GeCKO (pGeCKO) library targeting protein-coding genes, lncRNAs, and miRNAs was used. Genomic DNA was harvested from GeCKO cell populations at four t...
ORGANISM(S): Salmo salar 
2025-08-30 | E-MTAB-15487 | biostudies-arrayexpress
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