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TranscriptomicsDNA methylome signature in rheumatoid arthritis
Objectives: Epigenetics can influence disease susceptibility and severity. While DNA methylation of individual genes has been explored in autoimmunity, no unbiased systematic analyses have been reported. Therefore, a genome-wide evaluation of DNA methylation loci in fibroblast-like synoviocytes (FLS...
ORGANISM(S): Homo sapiens 
2013-04-25 | E-GEOD-46364 | biostudies-arrayexpress
TranscriptomicsSystems-level analysis of N-starvation induced modifications of carbon metabolism in a Chlamydomonas starchless mutant
To understand the molecular basis underlying increased triacylglycerol accumulation in starchless Chlamydomonas mutants, we undertook comparative time course transcriptomics of sta6 (CC-4348), a cw strain purported to represent the parental STA6 strain (CC-4349), and 3 independent STA6 strains (STA6...
ORGANISM(S): Chlamydomonas reinhardtii 
2013-10-24 | E-GEOD-51602 | biostudies-arrayexpress
ProteomicsRegulation of dendritic cells and macrophages by an anti-apoptotic cell natural Ab that inhibits inflammatory arthritis
Although natural antibodies (NAbs) are present from birth, little is known about what drives their selection, and whether they have housekeeping functions. We now show that the prototypic T15-NAb, first identified because of its protective role in infection, is representative of a previously unknown...
ORGANISM(S): unidentified 
2010-05-06 | E-GEOD-14969 | biostudies-arrayexpress
UnknownGenetic modulation of lipid profiles following lifestyle modification or metformin treatment: the Diabetes Prevention Program.
Not available
S-EPMC3431328 | biostudies-literature
GenomicsMarra_DLBCL_validation - samples
miRNA-seq Cohort of 140 Formalin Fixed Paraffin Embedded Diffuse Large B-cell Lymphoma Patient Samples
EGAD00001001073 | EGA
GenomicsMarra_DLBCL_discovery - samples
miRNA-seq Cohort of 92 Fresh Frozen Diffuse Large B-cell Lymphoma Patient Samples
EGAD00001001074 | EGA
GenomicsMarra_DLBCL_centroblast - samples
miRNA-seq Cohort of 15 Benign Centroblasts
EGAD00001001075 | EGA
GenomicsComprehensive miRNA Sequence Analysis Reveals Survival Differences in Diffuse Large B-cell Lymphoma Patients
Diffuse large B-cell lymphoma (DLBCL) is an aggressive disease, with 30-40% of patients failing to achieve complete responses to standard therapy. miRNAs are RNA molecules that attenuate expression of their mRNA targets. To characterize the DLBCL miRNome, we sequenced miRNAs from 92 DLBCL and 15 ben...
EGAS00001001025 | EGA
TranscriptomicsThe Detection and Subtyping of Seasonal Influenza A H1N1 Isolates Using a Microarray
An influenza A microarray was used to type influenza A H1N1 specimens collected in Washington State and the results compared with identification by both culture and real time RT PCR. The microarray was more sensitive than conventional influenza testing. Cluster analysis of the microarray data discri...
ORGANISM(S): Influenza A virus 
2008-10-31 | E-GEOD-12226 | biostudies-arrayexpress
GenomicsA novel recurrent mutation in MITF predisposes to familial and sporadic melanoma

We conducted whole-genome sequencing of probands from several melanoma families, identifying one individual carrying a novel germline variant (c.G1075A, NM_000248.3; p.E318K, NP_000239.1; rs149617956) in the melanoma lineage-specific oncogene MITF. While the variant cosegregated with melanoma in ...

phs000419.v1.p1 | EGA
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