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We set out to characterize the gene expression changes which take place during chondrogenesis in the developing mouse limb. RNA derived from pre-condensed mesenchyme, mesenchymal condensations, and cartilage anlagen representing the earliest stages of tibial and fibular development was analysed by ...
ORGANISM(S): Mus musculus 
MicroRNAs (miRNAs) regulate cartilage differentiation and contribute to the onset and progression of joint degeneration. These small RNA molecules may affect extracellular matrix organization (ECM) in cartilage, but for only a few miRNAs has this role been defined in vivo. Previously, we showed that...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-18 | PXD019374 | Pride
Interactome of overexpressed HA-tagged (2771, 2918) or Strep-tagged (3555, 3592) ALR in HEK293 FLP/IN/T-Rex cells vs control Mock under native (2771, 3592) or denaturing (2883, 3555) lysis conditions. For project 2771, an interactome of HA-tagged SOD2 was generated as additional negative control.
ORGANISM(S): Homo sapiens (Human) 
2026-04-16 | PXD064631 | Pride
Energy metabolism and extracellular matrix function are closely connected to orchestrate and maintain tissue organization, but the crosstalk is poorly understood. Here, we used scRNA-seq analysis to uncover the importance of respiration for extracellular matrix homeostasis in mature cartilage. Genet...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD027109 | Pride
Whole cell proteomics of a CRISPR/Cas9-generated HEK293 FLP/IN/T-Rex CPOX KO cell line in comparison to HEK293 FLP/IN/T-Rex WT cells and HEK293 FLP/IN/T-Rex CPOX KO cells complemented with CPOX-HA WT.
ORGANISM(S): Homo sapiens (Human) 
2026-04-16 | PXD064668 | Pride
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