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TranscriptomicsGlobal comparative transcriptome analysis of cartilage formation in vivo
We set out to characterize the gene expression changes which take place during chondrogenesis in the developing mouse limb. RNA derived from pre-condensed mesenchyme, mesenchymal condensations, and cartilage anlagen representing the earliest stages of tibial and fibular development was analysed by ...
ORGANISM(S): Mus musculus 
2012-02-10 | E-GEOD-35669 | biostudies-arrayexpress
ProteomicsAblation of the miRNA cluster 24 has profound effects on extracellular matrix protein abundance in cartilage
MicroRNAs (miRNAs) regulate cartilage differentiation and contribute to the onset and progression of joint degeneration. These small RNA molecules may affect extracellular matrix organization (ECM) in cartilage, but for only a few miRNAs has this role been defined in vivo. Previously, we showed that...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-18 | PXD019374 | Pride
Extracellular matrix  mirc24  mir-322  mir-503  cartilage  prg4  articular  sox9  sox6  mmp13 
ProteomicsSingle cell RNA-seq analysis links respiratory dysfunction to an extracellular matrix-specific damage response
Energy metabolism and extracellular matrix function are closely connected to orchestrate and maintain tissue organization, but the crosstalk is poorly understood. Here, we used scRNA-seq analysis to uncover the importance of respiration for extracellular matrix homeostasis in mature cartilage. Genet...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD027109 | Pride
Cartilage Respiration Ecm 
TranscriptomicsTranscription profiling of hind limbs from annexin A5 and A6 knock-out mice
Initiation of mineralisation during endochondral ossification is a multistep process and was assumed to correlate with specific interactions of annexins and collagens. Annexins A5 and A6 are postulated to represent the essential annexins promoting cartilage mineralisation. However, skeletal developm...
ORGANISM(S): Mus musculus 
2009-02-17 | E-MEXP-1718 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of human monocyte-derived macrophages stimulated with dexamethasone, interferon-gamma and dexamethasone/interferon-gamma
Glucocorticoids are extensively used to treat inflammatory diseases, however their chronic intake increases the risk of mycobacterial infections. Meanwhile, the effects of glucocorticoids on innate host responses are incompletely understood. Here, we studied the direct effects of glucocorticoids on ...
ORGANISM(S): Homo sapiens 
2016-05-30 | E-GEOD-79077 | biostudies-arrayexpress
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