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ProteomicsA mu opioid receptor superagonist that produces analgesia with minimal adverse effects
Developing safe and effective pain medications is an ongoing challenge for human health. Mu opioid receptor (MOR) agonists are essential pain medications, but their high intrinsic efficacy induces adverse side effects, including respiratory depression, constipation, tolerance, dependence, withdrawal...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD062863 | Pride
Mor Apex Opioids 
ProteomicsEvaluation of Orbitrap Ascend Tribrid Mass Spectrometer for Shotgun Proteomics
The Orbitrap Ascend Tribrid mass spectrometer was systematically evaluated in the context of shotgun proteomics, and its performance was compared to that of the previous generation of Tribrid instrument - Orbitrap Eclipse
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2023-03-10 | MSV000091467 | MassIVE
MetabolomicsGNPS - MITOMICS: defining mitochondrial protein functions through deep multi-omic profiling
Mitochondria are epicenters of eukaryotic metabolism and bioenergetics. Pioneering efforts in recent decades have established the core protein componentry of these organelles and have linked their dysfunction to over 150 distinct disorders. However, hundreds of mitochondrial proteins still lack clea...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-01-11 | MSV000086685 | GNPS
ProteomicsLarge-scale Multi-omic Analysis of COVID-19 Severity
We performed RNA-Seq and high-resolution mass spectrometry on 128 blood samples from COVID-19 positive and negative patients with diverse disease severities. Over 17,000 transcripts, proteins, metabolites, and lipids were quantified and associated with clinical outcomes in a curated relational datab...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-07-08 | MSV000085703 | MassIVE
ProteomicsMITOMICS: defining mitochondrial protein functions through deep multi-omic profiling
Mitochondria are epicenters of eukaryotic metabolism and bioenergetics. Pioneering efforts in recent decades have established the core protein componentry of these organelles and have linked their dysfunction to over 150 distinct disorders. However, hundreds of mitochondrial proteins still lack clea...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-01-11 | MSV000086685 | MassIVE
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