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ProteomicsIntracellular targets of the opioids
Opioids are powerful analgesics but carry many contingencies that can lead to opioid-use disorder. Significant energy has been invested in understanding the molecular actions of the opioid alkaloids, particularly their relationship with the opioid receptors at the cell surface. However, there is gro...
ORGANISM(S): Homo sapiens (Human) 
2024-05-07 | PXD045676 | Pride
Heroin Morphine Opioids Lc-ms/ms 
GenomicsEffects of HIV infection and opioids on gut microbiota
Effects of HIV infection and opioids on gut microbiota
PRJEB33325 | ENA
TranscriptomicsEffects of HIV infection and opioids on gut microbiota
Opioid use is associated with worse outcome in HIV-infected patients. The exacerbated disease progression by opioids is mainly driven by increased epithelial damage and less regenerative response. The present study investigates how opioids potentiate HIV disease progression by impairing intestinal e...
ORGANISM(S): Mus musculus 
2020-01-11 | E-MTAB-7883 | biostudies-arrayexpress
GenomicsEffect of short-term prescription opioids on DNA methylation of the OPRM1 promoter
Effect of short-term prescription opioids on DNA methylation of the OPRM1 promoter
PRJNA635945 | ENA
GenomicsMorphine treatment leads to temporal modulation of the gut microbiome
Opioid analgesics are frequently prescribed in the United States and worldwide. However, serious side effects such as addiction, immunosuppression and gastrointestinal symptoms limit long term use. In the current study using a chronic morphine-murine model a longitudinal approach was undertaken to i...
ORGANISM(S): mouse gut metagenome 
2018-04-16 | E-MTAB-5550 | biostudies-arrayexpress
Methylation profilingEffect of short-term prescription opioids on DNA methylation of the OPRM1 promoter
Evaluate the effect of short-term use of precribed opioids on DNA methylation
ORGANISM(S): Homo sapiens 
2020-05-30 | GSE151485 | GEO
GenomicsMorphine treatment induces distinct changes in the gut microbiome at day 3 post treatment
Opioids such as morphine have many beneficial properties as analgesics, however, opioids may induce multiple adverse gastrointestinal symptoms. We have recently demonstrated that morphine treatment results in significant disruption in gut barrier function leading to increased translocation of gut co...
ORGANISM(S): mouse gut metagenome 
2018-04-16 | E-MTAB-5546 | biostudies-arrayexpress
ClinicalPrevention of constipation during treatment with opioids: magnesiumoxide versus macrogol/elektrolytes
Primary objectives: To compare magnesiumoxide and Movicolon with regard to the prevention of constipation in palliative care cancer patients started on opioids Primary endpoints: Level of constipation (as assessed by the PAC SYM, a constipation symptom assessment instrument)
2523670 | ecrin-mdr-crc
UnknownExperiences and perspectives of adults on using opioids for pain management in the postoperative period: A scoping review protocol.
Not available
S-EPMC11783630 | biostudies-literature
UnknownPreferred pharmaceutical-grade opioids to reduce the use of unregulated opioids: A cross-sectional analysis among people who use unregulated opioids in Vancouver, Canada.
Not available
S-EPMC12279256 | biostudies-literature
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