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TranscriptomicsTranscription profiling of mouse striatum treated with morphine, animals from four inbred strains
Chronic opiate use produces molecular and cellular adaptations in the nervous system, leading to tolerance, physical dependence and addiction. Genome-wide comparison of morphine-induced changes in brain transcription of mouse strains with different opioid-related phenotypes provides an opportunity t...
ORGANISM(S): Mus musculus 
2009-02-07 | E-GEOD-7762 | biostudies-arrayexpress
TranscriptomicsEffect of short- and long-term morphine treatment on gene expression in the hypothalamus and pituitary
Addictive drugs including opioids activate signal transduction pathways that regulate gene expression in the brain. However, changes in CNS gene expression following morphine exposure are poorly understood. We studied the effect of short- and long-term morphine treatment on gene expression in the hy...
ORGANISM(S): Mus musculus 
2008-09-30 | E-GEOD-9525 | biostudies-arrayexpress
TranscriptomicsEffects of neonatal stress and morphine on murine hippocampal gene expression
Critically ill preterm infants experience multiple stressors while hospitalized. Morphine is commonly prescribed to ameliorate their pain and stress. We hypothesized that neonatal stress will have a dose-dependent effect on hippocampal gene expression, and these effects will be altered by morphine t...
ORGANISM(S): Mus musculus 
2013-08-30 | E-GEOD-50382 | biostudies-arrayexpress
TranscriptomicsWhole-genome expression profile in zebrafish embryos after chronic exposure to morphine
A great number of studies have investigated changes induced by morphine exposure in gene expression using several experimental models. In this study, we examined gene expression changes during chronic exposure to morphine during maturation and differentiation of zebrafish CNS. Our study identified d...
ORGANISM(S): Danio rerio 
2014-09-04 | E-GEOD-61062 | biostudies-arrayexpress
TranscriptomicsSelective boosting of transcriptional and behavioral responses to drugs of abuse by histone deacetylase inhibition
Histone acetylation and other modifications of the chromatin are important regulators of gene expression and, consequently, may contribute to drug-induced behaviors and neuroplasticity. Previous studies have shown that a reduction on histone deacetylase (HDAC) activity results on the enhancement of ...
ORGANISM(S): Mus musculus 
2010-09-17 | E-GEOD-17731 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of dorsal root ganglion (DRG) gene expression after morphine or oxycodone treatment
Analyse of gene expression modification after chronic analgesic treatment. The hypothesis tested in the present study was that oxycodone and morphine induced gene expression modification. Results provide important information to understand the analgesic effects of oxycodone as compared to morphine i...
ORGANISM(S): Rattus norvegicus 
2014-01-09 | E-GEOD-53897 | biostudies-arrayexpress
GenomicsEffect of morphine treatment on microbiome in the context of microbial transplant.
Morphine causes microbial dysbiosis. In this study we focused on restoration of native microbiota in morphine treated mice and looked at the extent of restoration and immunological consequences of this restoration. Fecal transplant has been successfully used clinically, especially for treating C. di...
ORGANISM(S): Mus musculus domesticus 
2016-06-01 | E-MTAB-3723 | biostudies-arrayexpress
GenomicsMorphine treatment induces distinct changes in the gut microbiome at day 3 post treatment
Opioids such as morphine have many beneficial properties as analgesics, however, opioids may induce multiple adverse gastrointestinal symptoms. We have recently demonstrated that morphine treatment results in significant disruption in gut barrier function leading to increased translocation of gut co...
ORGANISM(S): mouse gut metagenome 
2018-04-16 | E-MTAB-5546 | biostudies-arrayexpress
GenomicsMorphine treatment leads to temporal modulation of the gut microbiome
Opioid analgesics are frequently prescribed in the United States and worldwide. However, serious side effects such as addiction, immunosuppression and gastrointestinal symptoms limit long term use. In the current study using a chronic morphine-murine model a longitudinal approach was undertaken to i...
ORGANISM(S): mouse gut metagenome 
2018-04-16 | E-MTAB-5550 | biostudies-arrayexpress
TranscriptomicsmicroRNA expression and opioid signaling
To study the relationship between microRNAs and μ-opioid receptor (MOR) signaling, we examined microRNA expression after chronic morphine or fentanyl treatment in rat primary hippocampal neurons and in mouse hippocampus. Mouse cerebellum region was also tested as a negative control to eliminate mic...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-14268 | biostudies-arrayexpress
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