Whole-genome expression profile in zebrafish embryos after chronic exposure to morphine

ABSTRACT: A great number of studies have investigated changes induced by morphine exposure in gene expression using several experimental models. In this study, we examined gene expression changes during chronic exposure to morphine during maturation and differentiation of zebrafish CNS. Our study identified different functional classes of genes and individual candidates involved in the mechanisms underlying susceptibility to morphine actions related to CNS development. These results open new lines to study the treatment of pain and the molecular mechanisms involved in addiction. We also found a set of zebrafish-specific morphine-induced genes, which may be putative targets in human models for addiction and pain processes. Zebrafish embryos were divided into two experimental groups: control embryos a

ORGANISM(S): Danio rerio

SUBMITTER: Raquel Rodriguez 

PROVIDER: E-GEOD-61062 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress