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TranscriptomicsTargeted disruption of BMAL1 in the peripheral reproductive axis results in infertility in female mice
The product of the Bmal1 locus is an essential component of the circadian clock that plays important roles in various aspects of reproductive biology,and when disrupted results in infertility. In an effort to establish the identity of the tissue specific clock that is responsible for this infertilit...
ORGANISM(S): Mus musculus 
2014-10-01 | E-GEOD-48758 | biostudies-arrayexpress
TranscriptomicsThe Autonomous Hepatocyte Clock Controls Acetaminophen Bioactivation and Chronotoxicity [Kidney]
The diurnal variation in acetaminophen (APAP) hepatotoxicity (“chronotoxicity”) is thought to be due to oscillations in xenobiotic metabolism that are influenced by the circadian phases of feeding or fasting. Because of APAP’s relevance to human poisoning, we set out to determine the relative contr...
ORGANISM(S): Mus musculus 
2013-08-30 | E-GEOD-34443 | biostudies-arrayexpress
TranscriptomicsThe Autonomous Hepatocyte Clock Controls Acetaminophen Bioactivation and Chronotoxicity [Liver]
The diurnal variation in acetaminophen (APAP) hepatotoxicity (“chronotoxicity”) is thought to be due to oscillations in xenobiotic metabolism that are influenced by the circadian phases of feeding or fasting. Because of APAP’s relevance to human poisoning, we set out to determine the relative contr...
ORGANISM(S): Mus musculus 
2013-08-30 | E-GEOD-34442 | biostudies-arrayexpress
TranscriptomicsTargeted disruption of BMAL1 in the peripheral reproductive axis results in infertility in female mice.
The product of the Bmal1 locus is an essential component of the circadian clock that plays important roles in various aspects of reproductive biology, and its disruption results in infertility. In an effort to identify the identity of the tissue specific clock that is responsible for this infertilit...
ORGANISM(S): Mus musculus 
2013-02-01 | E-GEOD-38365 | biostudies-arrayexpress
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