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GenomicsGC-rich Sequence Elements Recruit Polycomb Repressive Complex 2 (PRC2) in ES cells
Polycomb proteins are epigenetic regulators that localize to developmental loci in the early embryo where they mediate lineage-specific gene repression. In Drosophila, these repressors are recruited to sequence elements by DNA binding proteins associated with Polycomb repressive complex 2 (PRC2). Ho...
ORGANISM(S): Mus musculus 
2010-11-23 | E-GEOD-25197 | biostudies-arrayexpress
UnknownDNA binding and lesion recognition by the bacterial interstrand DNA crosslink glycosylase AlkX
Not available
S-SCDT-10_1038-S44319-026-00785-6 | biostudies-other
MetabolomicsGNPS_Dysidea granulosa
Sponge collected by snorkel at Piti Bomb Holes in Guam
ORGANISM(S): Dysidea Granulosa 
2014-11-05 | MSV000078924 | GNPS
MetabolomicsGNPS_Lamellodysidea herbacea
Sponge was collected at Anae Island in Guam by scuba.
ORGANISM(S): Lamellodysidea Herbacea 
2014-11-05 | MSV000078923 | GNPS
MetabolomicsGNPS-In vitro reaction of CYP450 Bmp7 with 2,4-dibromophenol substrate
In vitro reaction of CYP450 Bmp7 with 2,4-dibromophenol substrate
ORGANISM(S): In Vitro Reaction Of Cyp450 Bmp7 With 2,4-dibromophenol Substrate 
2014-11-05 | MSV000078925 | GNPS
GenomicsGenome-wide maps of chromatin state in pluripotent and lineage-committed cells
Genome-wide maps of chromatin state (H3K4me3, H3K9me3, H3K27me3, H3K36me3, H4K20me3) in pluripotent and lineage-committed cells We report the application of single-molecule-based sequencing technology for high-throughput profiling of histone modifications in mammalian cells. By obtaining over four b...
ORGANISM(S): Mus musculus 
2008-07-24 | E-GEOD-12241 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse ES cells, neural precursor cells and embryonic fibroblasts
Expression profiles for isogenic (129SvJae x C57BL/6) murine embryonic stem (ES) cells, neural precursors (NPC) obtained through in vitro differentiation of the ES cells, and embryonic fibroblasts (MEF) obtained at day 13.5. Experiment Overall Design: 3 replicates of wt ES cells, 3 replicates of wt...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-8024 | biostudies-arrayexpress
GenomicsMapping polycomb complexes in human and mouse embryonic stem cells
In embryonic stem (ES) cells, bivalent chromatin domains with overlapping repressive (H3 lysine 27 tri-methylation) and activating (H3 lysine 4 tri-methylation) histone modifications mark the promoters of more than 2000 genes. To gain insight into the structure and function of bivalent domains, we m...
ORGANISM(S): Mus musculus 
2008-11-01 | E-GEOD-13084 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic stem cell-derived astrocytes
Expression profiles for Gfap-positive astrocytes obtained by in vitro differentiation of 129SvJae x C57BL/6 murine embryonic stem (ES) cells. Generated to examine the relationship between expression levels and DNA methylation patterns. Experiment Overall Design: 3 replicates of ES-derived astrocyte...
ORGANISM(S): Mus musculus 
2008-10-20 | E-GEOD-11483 | biostudies-arrayexpress
TranscriptomicsGene expression by myriocin treatment
Studies of aging and longevity are revealing how diseases that shorten life can be controlled to improve the quality of life and lifespan itself. Two strategies under intense study to accomplish this goal are rapamycin treatment and calorie restriction. New strategies are being discovered includin...
ORGANISM(S): Saccharomyces cerevisiae 
2014-09-22 | E-GEOD-41362 | biostudies-arrayexpress
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