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MetabolomicsExtracellular Vesicles from probiotics mediated Walnut green husk polysaccharide alleviates ochratoxin-A-induced cognitive impairment via SCFA and 5-HT mediated microbiota-gut-brain axis

BACKGROUND: Ochratoxin A (OTA) have made it a serious hazard to food safety worldwide that poses a serious health risk to humans. Our previous research showed that Walnut green husk polysaccharides (WGP) can effectively alleviate intestinal inflammation and intestinal microbiota ...

2024-10-10 | MTBLS10673 | MetaboLights
TranscriptomicsExtracellular Matrix Formation Enhances the Ability of Streptococcus pneumoniae to Cause Invasive Disease
Background. During infection, pneumococci exist mainly in sessile biofilms rather than in planktonic form, except during sepsis. However, relatively little is known about how biofilms contribute to pneumococcal pathogenesis. Methods. We performed a biofilm assay and mouse infection experiments on op...
ORGANISM(S): Streptococcus pneumoniae 
2011-04-20 | E-BUGS-117 | biostudies-arrayexpress
TranscriptomicsAnalysis of extracellular matrix and adhesion molecules expression in ALL cell line
The acute lymphoblastic leukemia cells lines JM-1, REH, Nalm-27, and SUP-B15 were analyzed for baseline expression of extacellular matrix and adhesion molecules using a pathway focused cDNA microarray (SABiosciences). RNA isolated from the ALL cell lines JM-1, REH, Nalm-27, and SUP-B15 was analyzed ...
ORGANISM(S): Homo sapiens 
2010-05-01 | E-GEOD-18516 | biostudies-arrayexpress
ProteomicsPorcine brain tissue-derived decellularized extracellular matrix LC-MS/MS
The protein composition of porcine brain tissue-derived decellularized extracellular matrix was identified.
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2023-11-24 | PXD046191 | Pride
Porcine Brain Decellularized extracellular matrix Lc-ms/ms 
TranscriptomicsscRNAseq datasets of human brain organoids generated for the manuscript "Morphodynamics of human early brain organoids
Here we have provided scRNAseq datasets of unguided human brain organoids. The organoids were sequenced as a 1) Timecourse, 2) With different extracellular matrix treatments, 3) chemical treatment and 4) from organoids ere generated with a gene knockout cell line. Brain organoids enable the mechanis...
ORGANISM(S): Homo sapiens 
2025-04-30 | E-MTAB-15057 | biostudies-arrayexpress
ProteomicsCombination of a microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids
Brain organoids derived from human pluripotent stem cells provide a highly valuable in vitro model to recapitulate human brain development and neurological diseases. However, the current systems for brain organoid culture require further improvement for the reliable production of high-quality organo...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) Sus scrofa domesticus (domestic pig) 
2021-06-02 | PXD025397 | Pride
Brain extracellular matrix Microfluidic device Organoid 
ProteomicsProteomic characterization of extracellular matrix (ECM) produced by human fibroblast activation protein (FAP)-positive pericyte-like cells and glioma cells
Fibroblast activation protein (FAP) is upregulated in most cancers and represents an emerging theranostic target in oncology. In glioblastoma (GBM), FAP is predominantly expressed in mesenchymal pericyte-like cells, which contribute to GBM progression by promoting angiogenesis and glioma cell prolif...
ORGANISM(S): Homo Sapiens 
PXD045057 | panorama
UnknownBrain extracellular matrix retains connectivity in neuronal networks.
Not available
S-EPMC4586818 | biostudies-literature
ProteomicsIncreased levels of extracellular matrix proteins in extracellular vesicles from brains of aged mice.
Extracellular vesicles (EVs) have several functions in the brain, serving as a mode of intercellular communication and as a pathway for disposal of cellular debris. While these functions serve to maintain healthy brain function, they may also contribute to diseases affecting the brain. EVs also chan...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD052797 | Pride
Aging Extracellular vesicles Extracellular matrix Lcms Mouse model Proteomics 
ProteomicsExtracellular matrix proteolysis maintains synapse plasticity during brain development
Maintaining a dynamic neuronal synapse pool is critical to brain development. The extracellular matrix (ECM) regulates synaptic plasticity via mechanisms that are still being defined and are studied predominantly in adulthood. Using live imaging of excitatory synapses in zebrafish hindbrain we obser...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2026-03-16 | PXD069328 | Pride
Zebra fish  brain  lc-msms  extracellular  biotinylation 
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