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MetabolomicsPorcine epidemic diarrhea virus manipulates IMPDH-dependent nucleotide biosynthesis to facilitate replication

Porcine epidemic diarrhea virus (PEDV) causes acute intestinal disease in pigs and remains a major threat to the global swine industry due to its high morbidity and mortality in neonatal piglets. To investigate host metabolic alterations upon PEDV infection, we performed untargeted metabolomic pr...

2025-10-17 | MTBLS13153 | MetaboLights
MetabolomicsCycloleucine disturbs functions of porcine Sertoli cells via modulating gene expression and metabolism

Cycloleucine (CL) is a methyl donor inhibitor. Our previous findings showed that CL could affect meiotic maturation and developmental potency of porcine oocytes by reducing nucleic acid N6-methyladenosine (m6A) epigenetic modification level. However, the effects of CL on porcine male reproduction...

2025-09-13 | MTBLS12990 | MetaboLights
MetabolomicsComprehensive multi-omics analysis reveals the influence of epigenetic mechanisms on porcine oocyte maturation
In vitro maturation (IVM) oocyte is a key component of assisted reproduction in pigs. Asynchronous nucleoplasmic maturation and incomplete cytoplasmic maturation is one of the key factors for impaired maturation and quality of oocytes matured in vitro. Although Single-omics techniques have been appl...
2025-08-27 | MTBLS12325 | MetaboLights
MetabolomicsMelatonin enhances function of porcine immature Sertoli cells via modulating gene expression and metabolism

Melatonin (MT), a neurohormone synthesized and secreted primarily by the pineal gland, is of vital function to animal reproduction. However, the effect of MT treatment on porcine immature Sertoli cells (iSCs) remains unclear. Here, MT treatment (10 nM, 36 h) could elevate mitochondrial function a...

2025-01-06 | MTBLS11126 | MetaboLights
MetabolomicsIdentification of Biomarkers using Metabolomics in Porcine Hemorrhagic Shock
Hemorrhagic shock with injury results in alterations of the metabolic state of an organism, which contribute to organ dysfunction and death. Previous investigations have explored the effects of carbohydrate prefeed in murine models but few in clinically relevant large animal models. We performed car...
2015-01-31 | MTBLS123 | MetaboLights
MetabolomicsMetabolite of esculetin plays an important role in cytotoxic effects induced by chloroquine on porcine immature Sertoli cells

Chloroquine (CQ) is widely used in the therapy against malarial, tumor and recently the COVID-19 pandemic, as a lysosomotropic agent to inhibit the endolysosomal trafficking in the autophagy pathway. We previously reported that CQ (20 µM, 36 h) could reprogram transcriptome and impair multiple si...

2024-07-08 | MTBLS9273 | MetaboLights
MetabolomicsProfile of key metabolites and identification of HMGCS1-DHEA pathway in porcine Sertoli cells treated by Vitamin C
Vitamin C (Ascorbic acid, AA), as vital micro-nutrient, plays an essential role for male animal reproduction. Previously, we showed that vitamin C reprogrammed the transcriptome and proteome to change phenotypes of porcine immature Sertoli cells (iSCs). Here, we used LC-MS-based non-targeted metabol...
2024-07-31 | MTBLS9673 | MetaboLights
MetabolomicsButyric acid derived from porcine-derived antioxidant probiotic PGM326 enhances intestinal cell differentiation by promoting oxidative phosphorylation

This study not only identified an efficient host-homologous antioxidant probiotic, PGM326, but also systematically elucidated its mechanism of exerting antioxidant function by synthesizing BA to promote OXPHOS in intestinal epithelial cells, thereby enhancing cell differentiation. This provides a...

2026-02-01 | MTBLS13818 | MetaboLights
MetabolomicsImpact of microcin J25 on the porcine microbiome in a continuous culture model
Not available
ORGANISM(S): swine colonic microbiota 
ST002014 | MetabolomicsWorkbench
TranscriptomicsPulmonary alveolar macrophages (PAMs) of Tongcheng piglets response to HP-PRRSV infection in vivo
Porcine reproductive and respiratory syndrome (PRRS), caused by PRRS virus (PRRSV), is the most economically important disease in pig populations. Lung damage is one major pathological condition following PRRSV infection, often leading to animal death. In vivo, PRRSV productive infection occurs pred...
ORGANISM(S): Sus scrofa 
2012-06-30 | E-GEOD-22782 | biostudies-arrayexpress
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