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ProteomicsArzanol Biomolecular Targets - Chemoproteomic fishing identifies arzanol as a positive modulator of brain glycogen phosphorylase
The interactome of arzanol was investigated by MS-based chemical proteomics, a pioneering technology for small molecules target discovery. Brain glycogen phosphorylase (bGP), a key regulator of glucose metabolism so far refractory to small molecule modulation, was identified as the main high-affinit...
ORGANISM(S): Homo sapiens (Human) 
2019-03-25 | PXD011170 | Pride
Arzanol Chemical proteomics Brain glycogen phosphorylase 
ProteomicsA proteomic platform unveils the brain glycogen phosphorylase as a potential metabolic target for glioblastoma multiforme
In the last few years, several efforts have been ended to identify original strategies against gli-oblastoma multiforme (GBM): this requires a more detailed investigation of the molecular mechanism of GBM so that novel targets can be identified for new possible therapeutic agents. Here, using a combi...
ORGANISM(S): Homo sapiens (Human) 
2022-08-11 | PXD034933 | Pride
3-benzodiazepin-4-one Glycogen phosphorylase Proteomics 2 Target identification Glioblastoma multiforme 
UnknownInsights into Brain Glycogen Metabolism: THE STRUCTURE OF HUMAN BRAIN GLYCOGEN PHOSPHORYLASE.
Not available
S-EPMC5000057 | biostudies-literature
UnknownBrain-Type Glycogen Phosphorylase Is Crucial for Astrocytic Glycogen Accumulation in Chronic Social Defeat Stress-Induced Depression in Mice.
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S-EPMC8820374 | biostudies-literature
UnknownAn Isozyme-specific Redox Switch in Human Brain Glycogen Phosphorylase Modulates Its Allosteric Activation by AMP.
Not available
S-EPMC5104910 | biostudies-literature
UnknownBrain-Type Glycogen Phosphorylase (PYGB) in the Pathologies of Diseases: A Systematic Review.
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S-EPMC10854662 | biostudies-literature
UnknownBreast cancers utilize hypoxic glycogen stores via PYGB, the brain isoform of glycogen phosphorylase, to promote metastatic phenotypes.
Not available
S-EPMC6752868 | biostudies-literature
UnknownMolecular Mechanisms of Allosteric Inhibition of Brain Glycogen Phosphorylase by Neurotoxic Dithiocarbamate Chemicals.
Not available
S-EPMC5290938 | biostudies-literature
UnknownMuscle Glycogen Phosphorylase and Its Functional Partners in Health and Disease.
Not available
S-EPMC8070155 | biostudies-literature
UnknownKIAA1199 interacts with glycogen phosphorylase kinase β-subunit (PHKB) to promote glycogen breakdown and cancer cell survival.
Not available
S-EPMC4196182 | biostudies-literature
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