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MetabolomicsDisruption of the Brain-Spleen Axis Impairs Monocyte-Microglia Communication and Accelerates Disease Progression in a Mouse Model of Amyloidosis
Alzheimer’s disease (AD) is characterized by a prolonged asymptomatic phase before cognitive decline emerges, yet the mechanisms driving symptom onset remain unclear. Here, we hypothesized that the transition from asymptomatic to symptomatic disease is linked to dysfunction of brain–immune communica...
2026-06-01 | MTBLS14615 | MetaboLights
GenomicsGene expression patterns from hcfc1a Co60 brain homogenates.
Gene expression patterns from hcfc1a Co60 brain homogenates.
PRJNA549288 | ENA
ProteomicsProtein profiling and identification of new biomarkers of brain ischemia by MALDI-imaging-mass-spectrometry
Introduction The identification of proteins involved in brain ischemia might allow the discovery of new putative biomarkers or potential therapeutic target of one of the most important neurological disorders. MALDI Imaging-Mass-Spectrometry (IMS) is a powerful technique that allows the visualization...
ORGANISM(S): Mus musculus (Mouse) 
2016-12-14 | PXD003644 | Pride
Tmcao Biomarkers Brain ischemia Maldi imaging 
TranscriptomicsMicorRNA expression in klotho-deficient and wild-type mouse brain subregions
The expression profiles of miRNAs in klotho-deficient and wild-type mouse brain subregions were examined. The data indicated that little or no marked difference in the miRNA expression was detected between them. Twelve samples prevared from 4- or 5-week-old klotho-deficient and wild-type mouse brain...
ORGANISM(S): Mus musculus 
2011-06-08 | E-GEOD-29092 | biostudies-arrayexpress
ProteomicsMouse brain perivascular astrocyte endfoot proteome
Proteome analysis of isolated mouse brain blood vessels and perivascular astrocyte endfeet (PV-AEF) using DIA.
ORGANISM(S): Mus Musculus (mouse) 
2023-11-04 | PXD037949 | JPOST Repository
TranscriptomicsEpigenetic Transgenerational Alterations to Stress Response in Brain Gene Networks and Behaviour
Ancestral environmental exposures that promote epigenetic transgenerational inheritance influence all aspects of an individual’s life history. Stress experienced during adolescence can affect adult physiological and behavioural phenotypes. The current study utilized a systems biology approach to in...
ORGANISM(S): Rattus norvegicus 
2012-02-01 | E-GEOD-26737 | biostudies-arrayexpress
Genomics
metagenome sequence : mice brain were inoculated with tick homogenates
PRJNA599517 | ENA
ProteomicsBrain-derived and circulating EVs from hypoperfused mice, early AD and mixed dementias
In this project we provide profiling of brain-derived and circulating EVs LC-MS/MS data from mice subjected to bilateral common carotid stenosis (BCAS) and Sham controls. Furthermore, data from brain-derived EVs of early AD and mixed dementias (AD+CVD) is also provided.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-09-08 | PXD009093 | Pride
Extracellular vesicles Brain 
ProteomicsProteomics of Alzheimer's Disease mouse models - control dataset
Alzheimer’s disease (AD) is a neurodegenerative disease displaying plaques formed by the neurotoxic amyloid β-peptide (Aβ), and intracellular neurofibrillary tangles consisting of protein tau. However, how these pathologies relates to the massive neuronal death that occurs in AD brains remain elusiv...
ORGANISM(S): Mus musculus (Mouse) 
2015-07-29 | PXD001786 | Pride
Mouse brain 
ProteomicsIn vivo murine brain protein synthesis uncover the molecular physiological process in brain
Identification of proteins that are synthesised de novo in response to specific microenvironmental cues is critical for understanding the molecular mechanisms, which underpin vital physiological processes and pathologies. Here, we report that a brief period of pulsed SILAM (Stable Isotope Labeling o...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-23 | PXD013502 | Pride
Pulsed silam Psivom Brain physiology Actively translating protein 
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