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MetabolomicsLipid Profiles of Human Brain Tumors Obtained by High-Resolution Negative Mode Ambient Mass Spectrometry

Alterations in cell metabolism, including changes in lipid composition occurring during malignancy, are well characterized for various tumor types. However, a significant part of studies that deal with brain tumors have been performed using cell cultures and animal models. Here, we present a data...

2021-11-18 | MTBLS1558 | MetaboLights
MetabolomicsMetabolic differences between primary and brain metastatic breast tumors revealed by in vivo [U-¹³C]-glucose infusion in mice

Metastatic breast tumors must adapt to the metabolic constraints of their target tissues. To understand how tumor metabolism varies across sites, we compared glucose utilization in primary mammary fat pad (MFP) tumors and brain metastases derived from the breast cancer cell line MDA-MB-231. Tumor...

2025-12-30 | MTBLS13152 | MetaboLights
ProteomicsTumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis
Development of effective therapies against brain metastasis is currently hindered by limitations in our understanding of the molecular mechanisms driving it. Here we define the contributions of tumour-secreted exosomes to brain metastatic colonization and demonstrate that pre-conditioning the brain ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD015210 | Pride
Tumour exosomal cemi brain metastasis 
TranscriptomicsAn RNAi Screen Identifies TRRAP as a Regulator of Brain Tumor-Initiating Cell Differentiation
Glioblastoma multiforme is the most common and most aggressive type of primary brain tumor. The brain-infiltrative character of glioblastoma makes complete surgical removal of the tumor impossible and neither radiation nor current chemotherapy provide cure. Recent evidence shows that glioblastoma mu...
ORGANISM(S): Homo sapiens 
2011-03-14 | E-GEOD-27931 | biostudies-arrayexpress
ModelsIarosz2015 - brain tumor
The paper describes a model of brain tumor. Created by COPASI 4.25 (Build 207) This model is described in the article: Mathematical model of brain tumour with glia-neuron interactions and chemotherapy treatment Kelly C. Iarosz, Fernando S. Borges, Antonio M. Batista, Murilo S. Baptista, Regiane ...
2024-09-02 | BIOMD0000000775 | BioModels
UnknownAcceptance and commitment therapy for young brain tumour survivors: study protocol for an acceptability and feasibility trial.
Not available
S-EPMC8173289 | biostudies-literature
UnknownVerbal fluency as a quick and simple tool to help in deciding when to refer patients with a possible brain tumour.
Not available
S-EPMC8978365 | biostudies-literature
TranscriptomicsLINT - a novel dL(3)mbt containing complex represses malignant brain tumour signature genes
Drosophila melanogaster KC cells were treated with RNAi against dL(3)mbt, dLint1 or EGFP (control) and the resulting changes in gene expression were measured.
ORGANISM(S): Drosophila melanogaster 
2012-11-01 | E-MTAB-849 | biostudies-arrayexpress
MetabolomicsMitochondrial Transplantation of Brown Adipocytes Interferes with the Metabolism of Tumor Stem Cells and Inhibits the Recurrence of Brain Glioma after Operation

Glioblastoma multiforme (GBM) is highly aggressive, with treatment resistance and recurrence driven by metabolically plastic glioma stem cells (GSCs). Inspired by brown adipose tissue (BAT) thermogenesis, researchers transplanted BAT-derived mitochondria (BA-Mito) into GSCs, reducing stemness mar...

2025-08-27 | MTBLS12901 | MetaboLights
GenomicsBase resolution maps of mutations, 5-methylcytosine and 5-hydroxymethylcytosine, and transcriptome of blood, tumour and margin samples from a glioblastoma multiforme patient
Glioblastoma multiforme is the most common and aggressive type of brain cancer. Little is known about the complex relationship between genomic and epigenomic as tumour progresses. We present the following base resolution whole genome maps of matched tumour/margin and blood samples from a glioblastom...
ORGANISM(S): Homo sapiens 
2017-02-24 | E-MTAB-5171 | biostudies-arrayexpress
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