Brain-derived exosomes

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Departamento de Neuropatología Molecular. Instituto de Fisiología Celular. Universidad Nacional Autónoma de México (UNAM) (1)
VIB Department of Medical Protein Research, UGent Proteome Analysis and Bioinformatics Unit A. Baertsoenkaai 3 B9000 Gent Belgium (1)
Newcastle University Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE24HH, United Kingdom (1)
Department of Physical Education, Seoul National University, Seoul, Republic of Korea, 08826 (1)
PRISM - Unite INSERM U1192 Universite de Lille France (1)
DZNE Munich Neuroproteomics Feodor-Lynen-Str. 17 81377 Munich Germany (1)
Drug Discovery Lab, Department of Neurology, University of California, Los Angeles, CA 90095, USA (1)
Biomedical Research Foundation Academy of Athens- BRFAA, Centre of Basic Research, Athens, Greece (1)
Instituto de Investigaciones Sanitarias de Santiago de Compostela (1)
Life and Health Sciences Research Institute (ICVS), Medical School, University of Minho, Braga, Portugal (1)
1) Vascular Biology Program, Boston Children's Hospital, Boston, MA, United States 2) Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States (1)

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MicroRNA profiling of brain metastasis competent cell-derived exosomes

Objective of this work was to characterize the miRNA profile of exosomes isolated from brain-homing cell lines (MDA-MB-231BR, CTC1BMSM, and 70W) with their respective parental non-brain metastatic cell lines (MDA-MB-231P, CTC1P and MeWo). Exosomes derived from the six cell lines were isolated. Brain...

ORGANISM(S): Homo sapiens

2013-07-16 | E-GEOD-48934 | biostudies-arrayexpress

Tumor exosome integrins determine organotropic metastasis

Stephen Paget first proposed, in 1889, that organ distribution of metastases is a non-random event, yet metastatic organotropism remains one of the greatest mysteries in cancer biology. Here, we demonstrate that exosomes released by lung-, liver- and brain-tropic tumor cells fuse preferentially with...

ORGANISM(S): Homo sapiens

2015-06-17 | E-GEOD-68919 | biostudies-arrayexpress

Insulin Resistance Increases TNBC Aggressiveness and Brain Metastasis via Adipocyte-derived Exosomes

PRJNA1208516 | ENA

Inhibition of extracellular vesicle-derived miR-146a-5p decreases the progression of melanoma brain metastasis in vitro and in vivo

Development of melanoma brain metastasis is caused by an interaction between tumor cells and normal cells in the brain microenvironment. miRNAs delivered by exosomes derived from the tumor cells seem to prime the brain microenvironment, prior to extravasation of tumor cells into the brain. We invest...

ORGANISM(S): Homo sapiens

2023-09-29 | E-MTAB-11798 | biostudies-arrayexpress

Glioblastoma microvesicles transport RNA and proteins

Glioblastoma tumour cells release microvesicles (exosomes) containing mRNA, miRNA and angiogenic proteins. These microvesicles are taken up by normal host cells, such as brain microvascular endothelial cells. By incorporating an mRNA for a reporter protein into these microvesicles, we demonstrate th...

ORGANISM(S): Homo sapiens

2008-11-15 | E-GEOD-13470 | biostudies-arrayexpress

Differential intracellular trafficking of exosomes in microglia and astrocytes

Exosomes have emerged as key players in cell-to-cell communication in both physiological and pathological processes in the Central Nervous System. Thus far, the intracellular pathways involved in uptake and trafficking of exosomes within different cell types of the brain are poorly understood. In ou...

ORGANISM(S): Mus musculus (Mouse)

2023-07-20 | PXD038287 | Pride

Brain-derived exosomes α-synuclein ko mouse brain hemispheres (cd57bl6)

Hypoxia-responsive gene expression profile of U87 MG glioblastoma cells and their exosomes.

How cancer cells adapt to hypoxia during tumor development remains an important question. The hypothesis tested in the present study was that tumor cell-derived exosome vesicles (also known as microvesicles or extracellular vesicles) are mediators of hypoxia-dependent intercellular signaling in gli...

ORGANISM(S): Homo sapiens

2013-03-20 | E-GEOD-45301 | biostudies-arrayexpress

MicroRNA and protein profiling of brain metastasis competent cell-derived exosomes.

Not available

S-EPMC3774795 | biostudies-literature

Homo sapiens

MicroRNA profiling of brain metastasis competent cell-derived exosomes

PRJNA212330 | ENA

Uptake of Mesenchymal Stem Cell-Derived Exosomes in Mouse Brain through Intranasal Delivery.

Not available

S-EPMC12645106 | biostudies-literature