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MetabolomicsAirway metabolic profiling during Streptococcus pneumoniae infection identifies branched chain amino acids as signatures of upper airway colonisation

Streptococcus pneumoniae is a leading cause of community-acquired pneumonia and bacteraemia and is capable of remarkable phenotypic plasticity, responding rapidly to environmental change. Pneumococcus is a nasopharyngeal commensal, but is responsible for severe, acute infections followin...

2023-08-08 | MTBLS4591 | MetaboLights
MetabolomicsGut Microbial Genes and Metabolism for Methionine and Branched-Chain Amino Acids in Diabetic Nephropathy

Diabetic mellitus nephropathy (DMN) is a serious complication of diabetes and a major health concern. Although the pathophysiology of diabetes mellitus (DM) leading to DMN is uncertain, recent evidence suggests the involvement of the gut microbiome. This study aimed to determine the relationships...

2023-03-01 | MTBLS6331 | MetaboLights
GenomicsBranched Chain Amino Acids (BCAA) Modulate Metabolic Inflammation
Branched Chain Amino Acids (BCAA) Modulate Metabolic Inflammation
PRJNA1222928 | ENA
MetabolomicsPP2Cm Dysregulation Is Associated with Impaired BCAA Catabolism and cGAS-STING Activation in Diabetic Kidney Disease
Background and Aims:Branched-chain amino acids (BCAAs) are increasingly implicated in diabetic kidney disease (DKD), yet the role of protein phosphatase 2C mitochondrial (PP2Cm), encoded by PPM1K and regulating BCAA catabolism through the branched-chain α-ketoacid dehydrogenase (BCKDH) complex, rema...
2026-10-09 | MTBLS15967 | MetaboLights
ProteomicsThe branched-chain amino acid transporter AAT10.2 of Trypanosoma brucei is regulated by substrate availability
A phosphoproteome analysis of procyclic form T. brucei revealed many amino acid transporters (AATs) of the amino acid/auxin permease (AAAP) family with phosphorylated residues exclusively in their hydrophilic N-terminal domain. AAT10.2, which contained multiple phosphorylated residues, was further c...
ORGANISM(S): Trypanosoma brucei 
2026-09-14 | PXD079824 | Pride
Phosphoproteomics Amino acid Branched-chain amino acids Transport Parasite Substrate specificity Tb927.8.8300 
MetabolomicsGRSF1 Protects Against Heart Failure by Maintaining BCAA Homeostasis

BACKGROUND: Imbalances in cardiac branched-chain amino acid (BCAA) metabolism and mitochondrial homeostasis are implicated in the onset and development of heart failure. However, the mechanisms triggering the downregulation of cardiac BCAA metabolism in heart failure remain unclear. Here, we iden...

2025-10-19 | MTBLS13178 | MetaboLights
ProteomicsReprograming of Proteasomal Degradation by Branched Chain Amino Acid Metabolism
Branched chain amino acids (BCAAs) play an important role in energy and protein regulation. Defects in BCAA metabolism are linked to numerous pathologies, including diabetes, neurodegeneration, and premature aging. Isovaleric acidemia is a metabolic disease caused by defective leucine breakdown and ...
ORGANISM(S): Caenorhabditis elegans 
2022-09-22 | PXD028286 | Pride
C. elegans  ubiquitin  leucine catabolism  branched chain amino acid (bcaa)  bcat  ivd  isovaleric acidemia 
GenomicsReprograming of Proteasomal Degradation by Branched Chain Amino Acid Metabolism
Reprograming of Proteasomal Degradation by Branched Chain Amino Acid Metabolism
PRJNA769111 | ENA
GenomicsBranched chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control
Branched chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control
PRJNA472872 | ENA
TranscriptomicsComparison of RNA-seq of Actinobacillus pleuropneumoniae (WT and (p)ppGpp0) under the absence of branched chain amino acids
(p)ppGpp is a key player in reprogramming transcriptomes to respond to nutritional challenges. Here, we present a transcriptional and phenotypic differences of A. pleuropneumoniae grown in different chemically defined media in the absence of (p)ppGpp. We show that the deprivation of branch-chain ami...
ORGANISM(S): Actinobacillus pleuropneumoniae 
2019-11-28 | E-MTAB-8514 | biostudies-arrayexpress
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