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MetabolomicsSAR11 Cells Rely on Enzyme Multifunctionality to Transport and Metabolize a Range of Polyamine Compounds
In the ocean surface layer and cell culture, the polyamine transport protein PotD of SAR11 bacteria is often one of the most abundant proteins detected. Polyamines are organic cations at seawater pH produced by all living organisms and are thought to be an important component of dissolved organic ma...
2021-09-09 | MTBLS3146 | MetaboLights
MetabolomicsOsh2 mediates Candida resistance to miltefosine by regulating zymosterol transport
Miltefosine has been identified for its antifungal properties, yet the mechanisms underlying its action and the development of resistance remain unclear. In this study, we induced drug resistance in various Candida species through concentration gradient exposure, successfully obtaining a miltefosine...
2025-07-03 | MTBLS12270 | MetaboLights
MetabolomicsFatty acid transport protein 4 is required for incorporation of saturated ultralong-chain fatty acids into epidermal ceramides and monoacylglycerols
Fatty acid transport protein 4 (FATP4) is an acyl-CoA synthetase that is required for normal permeability barrier in mammalian skin. FATP4 (SLC27A4) mutations cause ichthyosis prematurity syndrome, a nonlethal disorder. In contrast, Fatp4-/- mice die neonatally from a defective barrier. H...
2021-07-15 | MTBLS1138 | MetaboLights
MetabolomicsElevated temperature accelerates leaf senescence and promotes leaf nitrogen transport to improve rice grain protein synthesis
Elevated temperatures during grain filling severely constrain rice yield and quality. Although additional nitrogen can mitigate the adverse effects of elevated temperature, both factors increase grain protein content, and the underlying physiological mechanisms remain poorly understood. Here, we con...
2026-06-17 | MTBLS14777 | MetaboLights
MetabolomicsApoplastic metabolomics reveals sugars as mesophyll messengers regulating guard cell ion transport under red light
Here we sought to identify mesophyll messenger(s) that promote stomatal opening under red light. We first established a method to isolate leaf apoplastic fluids from Arabidopsis thaliana and Vicia faba and ascertained that the apoplastic fluid enhances red light-induced stomatal opening. We then app...
2025-06-23 | MTBLS5383 | MetaboLights
MetabolomicsAmphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism, lipid transport and oxidative stress response

Amphotericin B is increasingly used in treatment of leishmaniasis. Here, fourteen independent lines of Leishmania mexicana and one L. infantum line were selected for resistance to either amphotericin B or the related polyene antimicrobial, nystatin. Sterol profiling revealed tha...

2022-09-22 | MTBLS2744 | MetaboLights
MetabolomicsFrom maternal metabolome to placental development: thiamine-driven placental Notch-PI3K/AKT pathway coordinates placental angiogenesis and nutrient transport
Maternal supplementation with thiamine during gestation and lactation promotes placental development and enhances offspring growth through activation of the Notch signaling pathway.
2025-07-30 | MTBLS12796 | MetaboLights
ProteomicsExtensive structural rearrangement of intraflagellar transport trains underpins bidirectional cargo transport
Bidirectional transport in cilia is carried out by polymers of the IFTA and IFTB protein complexes, referred to as anterograde and retrograde IFT “trains”. Anterograde trains deliver cargoes from the cell to the ciliary tip, then remodel into retrograde trains for cargo export. We set out to underst...
ORGANISM(S): Chlamydomonas Reinhardtii 
2024-08-21 | PXD049195 | JPOST Repository
ProteomicsExtensive structural rearrangement of intraflagellar transport trains underpins bidirectional cargo transport (Proteomics
Bidirectional transport in cilia is carried out by polymers of the IFTA and IFTB protein complexes, referred to as anterograde and retrograde IFT “trains”. Anterograde trains deliver cargoes from the cell to the ciliary tip, then remodel into retrograde trains for cargo export. We set out to underst...
ORGANISM(S): Chlamydomonas Reinhardtii 
2024-08-21 | PXD049260 | JPOST Repository
MetabolomicsSex-Driven Differences in the Rumen Microbe-Metabolite-Epithelial Transport Axis: An Integrated Multi-Omics Study of Rumen Function in Male and Female Zhongwei Goats
This study investigates sex-driven differences in rumen metabolism in male and female Zhongwei goats. Rumen fluid samples were analyzed using untargeted LC-MS metabolomics in both positive and negative ion modes. Metabolites were separated by ultra-high-performance liquid chromatography and detected...
2026-08-31 | MTBLS15319 | MetaboLights
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