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UnknownTumour budding-based grading as independent prognostic biomarker in HPV-positive and HPV-negative head and neck cancer.

Background

The prognostic significance of tumour budding (TB) and minimal cell nest size (MCNS) was shown in human papillomavirus (HPV)-negative head and neck squamous cell carcinomas (HNSCC). However, the optimisation of cutpoints, the prognostic impact in HPV-positive HNSCC, and the compar...
S-EPMC10241901 | biostudies-literature
UnknownIn Vivo Fluorescence Immunohistochemistry: Localization of Fluorescently Labeled Cetuximab in Squamous Cell Carcinomas.
Anti-EGFR (epidermal growth factor receptor) antibody based treatment strategies have been successfully implemented in head and neck squamous cell carcinoma (HNSCC). Unfortunately, predicting an accurate and reliable therapeutic response remains a challenge on a per-patient basis. Although significa...
S-EPMC4894408 | biostudies-literature
UnknownA comparison of clinically utilized human papillomavirus detection methods in head and neck cancer.
Detection of human papillomavirus (HPV) in head and neck cancer has therapeutic implications. In situ hybridization and immunohistochemistry for p16 are used by surgical pathologists. We compared the sensitivity and specificity of three popular commercial tests for HPV detection in head and neck squ...
S-EPMC3157570 | biostudies-literature
UnknownA ratiometric threshold for determining presence of cancer during fluorescence-guided surgery.

Background and objective

Fluorescence-guided imaging to assist in identification of malignant margins has the potential to dramatically improve oncologic surgery. However, a standardized method for quantitative assessment of disease-specific fluorescence has not been investigated. Introduced...
S-EPMC4510011 | biostudies-literature
UnknownApolipoprotein E Promotes Invasion in Oral Squamous Cell Carcinoma.
Oral squamous cell carcinoma (OSCC) patients generally have a poor prognosis, because of the invasive nature of these tumors. In comparing transcription profiles between OSCC tumors with a more invasive (worst pattern of tumor invasion 5) versus a less invasive (worst pattern of tumor invasion 3) pa...
S-EPMC5762938 | biostudies-literature
UnknownSafety and Tumor Specificity of Cetuximab-IRDye800 for Surgical Navigation in Head and Neck Cancer.

Purpose

Positive margins dominate clinical outcomes after surgical resections in most solid cancer types, including head and neck squamous cell carcinoma. Unfortunately, surgeons remove cancer in the same manner they have for a century with complete dependence on subjective tissue changes to...
S-EPMC4909371 | biostudies-literature
UnknownPathology-based staging for HPV-positive squamous carcinoma of the oropharynx.

Objective

The rapid worldwide rise in incidence of human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) has generated studies confirming this disease as an entity distinct from traditional OPSCC. Based on pathology, surgical studies have revealed prognosticators ...
S-EPMC5523818 | biostudies-literature
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