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Proteomics,MultiomicsPervasive, coordinated protein level changes driven by transcript isoform switching during meiosis in yeast
To better understand the gene regulatory mechanisms that program developmental processes, we carried out simultaneous, genome-wide measurements of mRNA, translation and protein through meiotic differentiation in budding yeast.
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2018-01-02 | MSV000081874 | MassIVE
ProteomicsSmall and large ribosomal subunit deficiencies lead to distinct gene expression signatures that reflect cellular growth rate
Levels of the ribosome, the conserved molecular machine that mediates translation, are tightly linked to cellular growth rate. In humans, ribosomopathies are diseases associated with cell-type-specific pathologies and reduced ribosomal protein (RP) levels. Because gene expression defects resulting f...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2018-10-12 | MSV000083033 | MassIVE
ProteomicsGlobal proteome remodeling during ER stress involves Hac1-driven expression of long undecoded transcript isoforms
Cellular stress responses often require transcription-based activation of gene expression to promote cellular adaptation. Whether general mechanisms exist for stress-responsive gene down-regulation is less clear. A recently defined mechanism enables both up- and down-regulation of protein levels for...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2018-06-12 | MSV000082454 | MassIVE
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