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MetabolomicsMechanistic insights into the biological activity of S-Sulfocysteine in CHO cells using a multi-omics approach
S-Sulfocysteine (SSC), a bioavailable L-cysteine derivative (Cys), is known to be taken up and metabolized in Chinese hamster ovary (CHO) cells used to produce novel therapeutic biological entities. To gain a deeper mechanistic insight into the SSC biological activity and metabolization, a multi-omi...
2024-08-08 | MTBLS7424 | MetaboLights
TranscriptomicsTranscription profile of B cells isolated from peripheral lymph nodes of wild-type vs CCR7-/- mice
We investigated the transcriptional profile of B cells isolated from peripheral lymph nodes of CCR7-/-C57BL/6 and C57BL/6 mice respectively. B cells were sorted as follows: CD19+, CD3-, CD11c-, CD11b-, NK1.1-, GR-1-. Very few genes were differentially regulated in CCR7-/- B cells, however the expres...
ORGANISM(S): Mus musculus 
2011-11-21 | E-GEOD-27885 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of an amylolytic yeast
The amylolytic S. cerevisiae strain WTPB-G and the wild-type strain (control) from a genetic background of FY23 were used to elucidate the effect brought about to a wild-type strain by the presence of an extrachoromosomal self-replicating element in the form of a recombinant multicopy plasmid. Strai...
ORGANISM(S): Saccharomyces cerevisiae 
2016-06-08 | E-MTAB-3545 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses of yeast cells to the presence of 200 nM Rapamycin or 5 mM caffeine
To comparatively analyze the transcriptional responses of yeast cells to the presence of rapamycin or caffeine the homozygous hoΔ/hoΔ strain of S. cerevisiae BY4743 were grown in fully controlled fermenters in the presence of 200 nM rapamycin or 5 mM caffeine. Cells were cultured overnight in YPD me...
ORGANISM(S): Saccharomyces cerevisiae 
2019-03-15 | E-MTAB-7373 | biostudies-arrayexpress
TranscriptomicsActivity of SigB Modulates Virulence Gene Expression in a Murine Staphylococcus aureus Infection Model but Does Not Influence the Host Kidney Gene Expression
Background. Infections caused by Staphylococcus aureus are associated with significant morbidity and mortality and are an increasing threat not only in hospital settings. The expression of the staphylococcal virulence factor repertoire is known to be affected by the alternative sigma factor B (SigB...
ORGANISM(S): Mus musculus 
2011-10-23 | E-GEOD-28540 | biostudies-arrayexpress
TranscriptomicsDynamics of Short-term transcriptomic response of S. cerevisiae to doxorubicin
Dynamics of short-term effects of doxorubicin, a chemotherapy agent, on S. cerevisiae cells were investigated. After five residence times at steady-state, Yeast cells in chemostat was introduced a doxorubicin pulse to get 20 µM initial doxorubicin concentration. Samples were collected at steady sta...
ORGANISM(S): Saccharomyces cerevisiae 
2022-01-12 | E-MTAB-10023 | biostudies-arrayexpress
TranscriptomicsComparative transcriptome analysis between original and evolved recombinant lactose-consuming S. cerevisiae strains
The engineering of Saccharomyces cerevisiae strains for lactose utilization has been attempted with the intent of developing high productivity processes for alcoholic fermentation of cheese whey. A recombinant S. cerevisiae flocculent strain that efficiently ferments lactose to ethanol was previousl...
ORGANISM(S): Saccharomyces cerevisiae 
2008-10-31 | E-GEOD-12433 | biostudies-arrayexpress
TranscriptomicsSteady-state hydrogen peroxide induces glycolysis via metabolic reroute in P. aeruginosa and S. aureus
GAPDHs from human pathogens S. aureus and P. aeruginosa can be readily inhibited by ROS-mediated direct oxidation of their catalytic active cysteines. Because of the rapid degradation of H2O2 by bacterial catalase, only steady-state but not one-dose treatment of H2O2 induces rapid metabolic reroute ...
ORGANISM(S): Pseudomonas aeruginosa MPAO1/P1 
2014-05-08 | E-GEOD-55528 | biostudies-arrayexpress
TranscriptomicsDynamics of two oscillation phenotypes in S. cerevisiae reveal a network of genome-wide transcriptional and cell cycle oscillators.
This SuperSeries is composed of the following subset Series: GSE30051: Dynamics of two oscillation phenotypes in S. cerevisiae[2hr] GSE30052: Dynamics of two oscillation phenotypes in S. cerevisiae[4hr]. Refer to individual Series
ORGANISM(S): Saccharomyces cerevisiae 
2012-04-16 | E-GEOD-30053 | biostudies-arrayexpress
TranscriptomicsTranscriptomic comparison of fructose and lipid grown cultures of Ralstonia eutropha H16
Whole genome gene expression analysis was examined with Ralstonia eutropha strain H16 cultures grown in PHB production medium (recipe per Peoples and Sinskey, 1989) containing fructose or trioleate as the main carbon source. The goal of this analysis was to determine the identity of the triacylglyc...
ORGANISM(S): Cupriavidus necator 
2010-08-26 | E-GEOD-21145 | biostudies-arrayexpress
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