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MetabolomicsMulti-omics characterization of acquired Olaparib resistance in BRCA1 and BRCA2 mutant breast cancer cell lines
Poly (ADP-ribose) polymerase inhibitors (PARPi) are widely used as targeted therapies against breast cancers with BRCA mutations. However, the development of resistance to PARPi poses a significant challenge for long-term efficacy of these therapies, warranting further understanding of mechanisms of...
2026-05-11 | MTBLS12109 | MetaboLights
MetabolomicsMetabolic study of BRCA1 knockout cells and WT cells in homo sapiens

BRCA1 mutations are a hallmark of hereditary ovarian cancer, strongly linked to deficiencies in homologous recombination (HR) DNA repair and impaired DNA replication fork protection. However, its roles in cancer progression beyond maintaining genomic integrity remain poorly understood. Through me...

2026-05-15 | MTBLS12245 | MetaboLights
TranscriptomicsEfficacy of carboplatin alone and in combination with ABT888 in intracranial murine models of BRCA-mutated and BRCA-wild-type triple negative breast cancer
Purpose:Triple negative breast cancer (TNBC) commonly metastasizes to the brain and predicts poor prognosis with limited therapeutic options. TNBC frequently harbors BRCA mutations translating to platinum sensitivity; platinum response may be augmented by additional suppression of DNA repair mechani...
ORGANISM(S): Homo sapiens 
2015-05-12 | E-GEOD-55399 | biostudies-arrayexpress
ModelsFA BRCA pathway
MOTIVATION: Fanconi anemia (FA) is a chromosomal instability syndrome originated by inherited mutations that impair the Fanconi Anemia/Breast Cancer (FA/BRCA) pathway, which is committed to the repair of DNA interstrand cross-links (ICLs). The disease displays increased spontaneous chromosomal aberr...
1778 | Cell Collective
GenomicsBRCA Mutation Status Shapes the Microenvironment of Pancreatic Adenocarcinoma
BRCA Mutation Status Shapes the Microenvironment of Pancreatic Adenocarcinoma
PRJNA859233 | ENA
GenomicsBRCA Mutation Status Shapes the Microenvironment of Pancreatic Adenocarcinoma
BRCA Mutation Status Shapes the Microenvironment of Pancreatic Adenocarcinoma
PRJNA859234 | ENA
ProteomicsCooperation of the NEIL3 and Fanconi Anemia/BRCA Pathways in Interstrand Crosslink Repair
The NEIL3 DNA glycosylase is a base excision repair enzyme that excises bulky base lesions from DNA. Although NEIL3 has been shown to unhook interstrand crosslinks (ICL) in Xenopus extracts, how NEIL3 participants in ICL repair in human cells and its corporation with the canonical Fanconi anemia (FA...
ORGANISM(S): Homo sapiens (Human) 
2020-01-20 | PXD016256 | Pride
Neil3 Psoralen interstrand crosslink Fanconi anemia 
TranscriptomicsA gene expression profile of BRCAness that is associated with outcome in ovarian cancer
A gene expression profile of BRCAness was defined in publicly available expression data of 61 patients with epithelial ovarian cancer (34 patients with BRCA-1 or BRCA-2 mutations and 27 patients with sporadic disease). This dataset is publicly available at http://jnci.oxfordjournals.org/cgi/content/...
ORGANISM(S): Homo sapiens 
2010-07-11 | E-GEOD-19829 | biostudies-arrayexpress
ProteomicsComparative multi-omic analysis of fallopian tube fimbria from BRCA mutation carriers and control women
Integrated transcriptomic, epigenomic, and proteomic analysis of histologically normal fallopian tubes (FTs) fimbria from BRCA mutant carriers and controls. This study was undertaken to test the hypothesis that there are molecular alterations in FTs from BRCA mutant carriers that contribute to field...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-03-17 | MSV000094339 | MassIVE
UnknownBRCA Challenge: BRCA Exchange as a global resource for variants in BRCA1 and BRCA2.
Not available
S-EPMC6324924 | biostudies-literature
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