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TranscriptomicssiRNA profiling if human MCF-7 cell line to investigate the role of FAK, dominant-negative FAK, FAK-CD and FAKsiRNA in MCF-7 human breast cancer cell tumorigenesis
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that plays an important role in proliferation, motility, adhesion, invasion, angiogenesis, and survival signaling. Focal adhesion kinase has been shown to be overexpressed in many types of tumors, including breast cancer at early stages o...
ORGANISM(S): Homo sapiens 
2009-08-22 | E-GEOD-11581 | biostudies-arrayexpress
GenomicsEffect of depletion of CDK4 on gene expression of MCF-7 breast cance cells
Effect of depletion of CDK4 on gene expression of MCF-7 breast cance cells
PRJNA1089108 | ENA
TranscriptomicsExpression data in NK150460 treated breast cancer cell lines
The purpose of this study is to investigate certain genes inuduced/reduced by NK150460, novel compound possessing antitumor activity. To identify genes, time course samples were prepared from NK150460 sensitive and insensitive breast cancer cell lines. By comparing patterns in both sensitive and res...
ORGANISM(S): Homo sapiens 
2014-09-19 | E-GEOD-61548 | biostudies-arrayexpress
ProteomicsBreast cancer tumors - System-wide Clinical Proteomics of Breast Cancer Reveals Global Remodeling of Tissue Homeostasis
The project analyzed 88 breast cancer clinical samples, including lymph node negative and positive primary tumors, lymph node metastases, and healthy tissue as control. All samples were combined with a super-SILAC mix that served as an internal standard for quantification.
ORGANISM(S): Homo sapiens (Human) 
2016-01-25 | PXD000815 | Pride
Er positive Lymph node negative Breast cance Luminal Lymph node positive 
UnknownHER2-targeted therapies in cancer: a systematic review.
Not available
S-EPMC10835834 | biostudies-literature
TranscriptomicsEffect of depletion of CDK4 on gene expression of MCF-7 breast cance cells
CDK4/6 inhibitors act as a cytostatic by targeting CDK4/6-cyclin D, and have achieved great success in hormone receptor-positive breast cancer treatment. Beyond cell cycle signaling pathway, recent research on non-cell cycle related functions of CDK4/6 has been blooming. Insights in this field may e...
ORGANISM(S): Homo sapiens 
2024-09-17 | GSE261797 | GEO
TranscriptomicsGene profile of breast cancer tumors with low and high FAK expression
The gene expression profiles were identified in breast cancer tumors with different level of FAK three tumors with low FAK expression identified by IHC and 3 tumors with high FAK expression. 2 triple-negative with low and one triple negative with high FAK expression was among these 6 samples
ORGANISM(S): Homo sapiens 
2014-02-01 | E-GEOD-53618 | biostudies-arrayexpress
UnknownThe direct effect of focal adhesion kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis.
Not available
S-EPMC3087335 | biostudies-literature
GenomicsHomo sapiens
Homo sapiens Raw sequence reads
PRJNA919410 | ENA
UnknownVascular endothelial growth factor receptor-3 promotes breast cancer cell proliferation, motility and survival in vitro and tumor formation in vivo.
Not available
S-EPMC3619978 | biostudies-literature
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