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TranscriptomicsThe genetics and regulatory logic of alternative polyadenylation in human lymphoblastoid cells
We set out to investigate genomic mechanisms by which alternative polyadenylation impacts gene expression and its variation across genetically distinct human individuals. We used 3’-end RNA-seq to maximize genome coverage and precision of transcript end positions, and to measure quantitative express...
ORGANISM(S): Homo sapiens 
2012-08-27 | E-GEOD-33154 | biostudies-arrayexpress
TranscriptomicsPolygenic and directional regulatory evolution across pathways in Saccharomyces
We assess the prevalence of polygenic evolution in pathways between the yeasts S. cerevisiae and S. bayanus. We first established short-read sequencing methods to detect cis-regulatory variation in a diploid hybrid between the species. We then formulated an analytic strategy to test for the scenar...
ORGANISM(S): Saccharomyces bayanus x Saccharomyces cerevisiae 
2010-02-22 | E-GEOD-19837 | biostudies-arrayexpress
TranscriptomicsIntegrating Large-Scale Functional Genomic Data to Dissect the Complexity of Yeast Regulatory Networks
A major goal of biology is the construction of networks that predict complex system behavior. We combine multiple types of molecular data, including genotypic, expression, transcription factor binding site (TFBS), and protein-protein interaction (PPI) data previously generated from a number of yeas...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-15 | E-GEOD-11111 | biostudies-arrayexpress
TranscriptomicsThe star-nosed mole reveals clues to the molecular basis of mammalian touch.
Little is known about the molecular mechanisms underlying mammalian touch transduction. To identify novel candidate transducers, we examined the molecular and cellular basis of touch in one of the most sensitive tactile organs in the animal kingdom, the star of the star-nosed mole. Our findings demo...
ORGANISM(S): Mus musculus 
2013-05-31 | E-GEOD-47480 | biostudies-arrayexpress
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