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MetabolomicsNicotinamide Riboside is Uniquely Bioavailable in People and Mice
Nicotinamide riboside (NR) is in wide use as an NAD+ precursor vitamin. Here we conducted experiments to determine the time and dose-dependent effects of NR on blood, liver and heart NAD+ metabolism in people and mice. We report that human blood cell NAD+ can rise as much as 2.7-fold with a single d...
2016-09-09 | MTBLS368 | MetaboLights
UnknownConformation control through concurrent N-H⋯S and N-H⋯O[double bond, length as m-dash]C hydrogen bonding and hyperconjugation effects.
Not available
S-EPMC8163419 | biostudies-literature
TranscriptomicsTranscription profiling of Arabidopsis Col-0 plants with wild type, arr1-1 knock-out, ARR1 over-expressor and ARR1-SRDX fusion protein over-expressor genotypes treated with 6-Benzyladenine for different lengths of time
Arabidopsis thaliana Col-0 plants and three other genotypes (ARR1 overexpressor, arr1-1 knockout, overexpressor of ARR1-SRDX fusion protein) were grown in liquid media (1/2 MS, 1 g/L sucrose, 0.5 g/L MES, pH 5.7) in a Percival AR-66L growth chamber at 24 oC, 16:8 h day:night cycle, and 100 µE light ...
ORGANISM(S): Arabidopsis thaliana 
2008-08-31 | E-MEXP-689 | biostudies-arrayexpress
MetabolomicsNAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome (Intracellular UPLC-MS assay)

Metabolic dysfunction is a primary feature of Werner syndrome (WS), a human premature aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase. WS patients exhibit severe metabolic phenotypes, but the underlying mechanisms are not understood, and whether the metabolic ...

2019-10-17 | MTBLS1223 | MetaboLights
UnknownVariations in reverse transcriptase and RNase H domain mutations in human immunodeficiency virus type 1 clinical isolates are associated with divergent phenotypic resistance to zidovudine.
Not available
S-EPMC2151428 | biostudies-literature
UnknownH&E-based MSI/MMR testing with AI in colorectal cancer: a multi-centred blinded evaluation.
Not available
S-EPMC12800188 | biostudies-literature
TranscriptomicsTranscriptional response of Pseudomonas aeruginosa PAO1 to human host defense peptide LL-37
In this experiment the transcriptional response of the opportunistic human pathogen Pseudomonas aeruginosa towards physiological concentrations of the major human host defense peptide LL-37 was investigated using microarrays. To this aim, three independent cultures of P. aeruginosa PAO1 were grown u...
ORGANISM(S): Pseudomonas aeruginosa 
2013-12-20 | E-MEXP-3970 | biostudies-arrayexpress
MetabolomicsBranched-chain ketoacids derived from cancer cells modulate macrophage polarization and metabolic reprogramming

Macrophages are prominent immune cells in the tumor microenvironment that can be educated into pro-tumoral phenotype by tumor cells to favor tumor growth and metastasis. The mechanisms that mediate a mutualistic relationship between tumor cells and macrophages remain poorly characterized. Here, w...

2022-10-03 | MTBLS4497 | MetaboLights
UnknownPrevalence of relevant early complications during the first 24 h on a normal ward in patients following PACU care after medium and major surgery: a monocentric retrospective observational study.
Not available
S-EPMC11442648 | biostudies-literature
TranscriptomicsTranscription profiling of Arabidopsis seedlings treated with 6-Benzyl adenine - time series
Time course of Arabidopsis seedlings treated with 6-Benzyl adenine dissolved in diluted KOH for 15 min or 2 hours
ORGANISM(S): Arabidopsis thaliana 
2008-06-11 | E-GEOD-1766 | biostudies-arrayexpress
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