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GenomicsGenetic Framework for GATA Factor Function in Vascular Biology
Vascular endothelial dysfunction underlies the genesis and progression of numerous diseases. Whereas the GATA transcription factor GATA-2 is expressed in endothelial cells and is implicated in coronary heart disease, it has been studied predominantly as a master regulator of hematopoiesis. As many q...
ORGANISM(S): Homo sapiens 
2011-08-11 | E-GEOD-29531 | biostudies-arrayexpress
GenomicsAutophagy driven by a master regulator of hematopoiesis
Developmental and homeostatic remodeling of cellular organelles is mediated by a complex process termed autophagy. The cohort of proteins that constitute the autophagy machinery function in a multistep biochemical pathway. Though components of the autophagy machinery are broadly expressed, autophagy...
ORGANISM(S): Homo sapiens 
2011-09-30 | E-GEOD-32491 | biostudies-arrayexpress
TranscriptomicsMouse primary megakaryocytes, wild type & NF-E2p45-deficient
To identify p45 target genes, we conducted gene expression profiling with p45-null megakaryocytes cultured from E14.5 fetal liver. Many genes encoding membrane proteins and enzymes related to platelet function, including Txas, Glycoprotein 6 (Gp6) and Selectin P (Selp), were repressed in the absence...
ORGANISM(S): Mus musculus 
2010-03-22 | E-GEOD-15581 | biostudies-arrayexpress
GenomicsGenome-wide maps of GATA factor occupancy in K562 cells
GATA factors interact with simple DNA motifs (WGATAR) to regulate critical processes, including hematopoiesis, but very few WGATAR motifs are occupied in genomes. Given the rudimentary knowledge of mechanisms underlying this restriction, and how GATA factors establish genetic networks, we used ChIP-...
ORGANISM(S): Homo sapiens 
2009-11-25 | E-GEOD-18868 | biostudies-arrayexpress
UnknownHeme-dependent induction of mitophagy program during differentiation of murine erythroid cells.
Not available
S-EPMC10161131 | biostudies-literature
GenomicsGATA-1 in proliferating and differentiating murine ES cell derived erythroid progenitors
This SuperSeries is composed of the following subset Series: GSE35379: Genome-wide occupancy map of GATA-1 in proliferating and differentiating murine ES cell derived erythroid progenitors (ES-EP) GSE35384: Transcriptome analysis of differentiating normal and leukemic erythroid progenitors Refer to ...
ORGANISM(S): Mus musculus 
2012-02-27 | E-GEOD-35385 | biostudies-arrayexpress
UnknownLong non-coding RNA-dependent mechanism to regulate heme biosynthesis and erythrocyte development.
Not available
S-EPMC6197277 | biostudies-literature
UnknownExpanded encyclopaedias of DNA elements in the human and mouse genomes.
Not available
S-EPMC7410828 | biostudies-literature
UnknownPerspectives on ENCODE.
Not available
S-EPMC7410827 | biostudies-literature
UnknownGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Not available
S-EPMC4835977 | biostudies-literature
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