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TranscriptomicsHypermethylation of miR-34b is associated with CREB overexpression and Myeloid Cell Transformation
Increased CREB levels and upregulation of its target genes expression resulted in increased myelopoiesis and colony formation. Class comparison between MDS patients at diagnosis and evolution in AML
ORGANISM(S): Homo sapiens 
2012-11-30 | E-GEOD-25300 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in 38 JMML patients and 9 healthy donors (Validation cohort)
Juvenile myelomonocytic leukemia (JMML) is a very rare and aggressive stem cell disease that mainly occurs in young children. RAS activation constitutes the core component of oncogenic signaling. In addition, the leukemic blasts of a quarter of JMML patients present with monosomy 7 (-7), whereas mor...
ORGANISM(S): Homo sapiens 
2015-12-23 | E-GEOD-71935 | biostudies-arrayexpress
TranscriptomicsMLL partner genes confer distinct biological and clinical signatures of pediatric AML, an AIEOP study
We retrospectively analyzed AML patients enrolled in the AIEOP since 2000, 42 patients with 11q23 rearrangement were analyzed by gene expression profile Gene expression analyses were performed to compare AML MLL partner genes (AF9, AF10, AF6, ENL, ELL, Septin 6, and AF1q) Keywords: Expression data ...
ORGANISM(S): Homo sapiens 
2011-04-21 | E-GEOD-19577 | biostudies-arrayexpress
TranscriptomicsGene exprssion profile classification predicts clinical outcome in juvenile myelomonocytic leukemia
Gene expression analysis identified a specific signature of differentially expressed genes discriminating good and poor responders in JMML patients. Gene expression signatures were analyzed on two EWOG patient cohorts of pediatric JMML patients. Keywords: Expression data Class comparison between AM...
ORGANISM(S): Homo sapiens 
2009-12-31 | E-GEOD-14858 | biostudies-arrayexpress
TranscriptomicsAnnexin 2A sustains glioblastoma cell dissemination and proliferation affecting patient prognosis
Glioblastoma (GBM) is the most devastating tumour of the brain, endowed with a fatal prognosis. Indeed, the complete eradication of cancer cell disseminated outside the GBM mass still remains a crucial issue. Given the reported strong association existing between Annexin 2A (ANXA2) expression and ce...
ORGANISM(S): Homo sapiens 
2016-07-24 | E-GEOD-76786 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of pediatric myelodysplastic syndrome (MDS) characterizes disease subtype and time to progression into acute myeloid leukemia (AML)
Identification of relevant subgroups in childhood MDS patients by gene expression analysis and gene involve in progression into AML Class comparison between different subgroups of pediatric MDS (class risk, classification subtype)
ORGANISM(S): Homo sapiens 
2012-02-29 | E-GEOD-29326 | biostudies-arrayexpress
TranscriptomicsRole of TAZ as mediator of Wnt signaling (SW480)
To investigate the role of TAZ downstream of the abberrant Wnt signaling in CRC cells, we compared the expression profiles of parental SW480 cells (empty vector) transfected with siControl, siTAZ, sibeta-catenin or reconstituted with wild type APC and transfected with siControl Keywords: expression...
ORGANISM(S): Homo sapiens 
2012-12-21 | E-GEOD-39904 | biostudies-arrayexpress
TranscriptomicsRole of TAZ as mediator of Wnt signaling (MII)
To investigate the role of TAZ downstream of APC and beta-catenin in mammary epithelial cells cells, we compared the expression profiles of MCF10-T1k (MII) cells transfected with siControl, siAPC, siAPC+siTAZ, sibeta-catenin, or sibeta-catenin+siTAZ. Keywords: expression profiling by array We colle...
ORGANISM(S): Homo sapiens 
2012-12-21 | E-GEOD-39902 | biostudies-arrayexpress
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