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TranscriptomicsChromatin immunoprecipitation and transcription of mouse liver in the presence or absence of exogenous glucocorticoid to identify direct targets of the glucocorticoid receptor
The purpose of this study was to identify direct targets of the glucocorticoid receptor (GR) using an orthogonal analysis. An expression study of mouse livers in the presence or absence of exogenous glucocorticoid complemented a genome-wide location analysis on chromatin from the same livers. Thes...
ORGANISM(S): Mus musculus 
2007-09-14 | E-CBIL-38 | biostudies-arrayexpress
no omics definedTranscription profiling of rat pancreatic beta-cells in response to double stranded RNA and IFNgamma exposure
Viral infections and local production of IFNgamma might contribute to beta-cell dysfunction/death in Type 1 diabetes. Double stranded RNA accumulates in the cytosol of viral-infected cells, and exposure of purified rat beta cells to dsRNA (polyinosinic-polycytidylic acid, PIC) in combination with IF...
ORGANISM(S): Rattus norvegicus 
2006-06-20 | E-CBIL-11 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type and C/EBPbeta deficient mice during a partial hepatectomy time series to identify transcriptional targets of C/EBPbeta
The aim of this experiment was to use microarray analysis to compare the response of wild type (WT) and C/EBPbeta deficient (KO) mice during a partial hepatectomy time course in hopes of identifying transcriptional targets of C/EBPbeta. In addition, the WT time course alone was examined to analyze m...
ORGANISM(S): Mus musculus 
2006-10-03 | E-CBIL-16 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of HNF4 alpha null mice to investigate the phenotype of dis-regulated insulin secretion and abnormal beta cell growth
The aim of this experiment was to use microarray analysis to examine the phenotype of dis-regulated insulin secretion and abnormal beta cell growth in HNF4 alpha null mice. These mice show impaired glucose tolerance and elevated fasting and fed plasma insulin levels. Rana Gupta from Klaus Kaestner...
ORGANISM(S): Mus musculus 
2006-09-05 | E-CBIL-6 | biostudies-arrayexpress
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