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MetabolomicsMultiomic profiling of iron-deficient infant monkeys reveals alterations in neurologically important biochemicals in serum and cerebrospinal fluid before the onset of anemia

The effects of iron deficiency (ID) during infancy extend beyond the hematologic compartment and include short- and long-term adverse effects on many tissues including the brain. However, sensitive biomarkers of iron-dependent brain health are lacking in humans. To determine whether serum and cer...

2022-07-12 | MTBLS3388 | MetaboLights
UnknownPatient-Reported Toxicity During Pelvic Intensity-Modulated Radiation Therapy: NRG Oncology-RTOG 1203.
Not available
S-EPMC6097832 | biostudies-literature
TranscriptomicsExpression analysis of Staphylococcus aureus USA300 LAC in response to vehicle and benzbromarone.
Compilation fo whole genome gene expression changes in Staphylococcus aureus USA300 LAC cultures grown in the presence of vehicle or the anti-gout drug benzbromarone. The drug was intially screened as effective against the agr quorum sensing system in Staphylococcus aureus AH1677. A microarray study...
ORGANISM(S): Staphylococcus aureus subsp. aureus USA300 
2014-03-19 | E-GEOD-55980 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse small intestines
Rb and E2F are thought to play antagonistic roles in celll proliferation. However, this model is based mostly from in vitro cell culture systems. We used small intestines to test this model in vivo. We found that deletion of E2f1-3 in the small intestine of mice suppressed the ectopic expression o...
ORGANISM(S): Mus musculus 
2010-01-19 | E-GEOD-16454 | biostudies-arrayexpress
TranscriptomicsHypothalamic expression differences between hypertensive BPH/2J and normotensive BPN/3J mouse strains
Identification of hypothalamic genes whose expression differs between high blood pressure (BPH/2J) and normal blood pressure (BPN/3J) Schlager mouse strains at age 6 weeks (young) and 26 weeks (mature) using Affymetrix GeneChip® Mouse Gene 1.0 ST Arrays. The whole hypothalamus was removed from young...
ORGANISM(S): Mus musculus 
2011-04-11 | E-GEOD-25076 | biostudies-arrayexpress
TranscriptomicsHypothalamic expression differences between hypertensive BPH/2J during circadian variations of blood pressure
Identification of hypothalamic genes whose expression differs between active (peak of blood pressure) and inactive periods in the high blood pressure (BPH/2J) Schlager mouse, adjusted by their age- and activity-matched normal blood pressure (BPN/3J) controls using Affymetrix GeneChip® Mouse Gene 1.0...
ORGANISM(S): Mus musculus 
2011-04-04 | E-GEOD-26007 | biostudies-arrayexpress
TranscriptomicsThe impact of a phytoestrogen-rich diet on cardiac gene expression in the context of HCM
A soy diet worsens the progression of an inherited form of hypertrophic cardiomyopathy (HCM) in male mice when compared to casein-fed mice. Females are largely resistant to this diet effect and better preserve cardiac function. We hypothesized that the abundant phytoestrogens found in soy are mainly...
ORGANISM(S): Mus musculus 
2011-06-02 | E-GEOD-29648 | biostudies-arrayexpress
UnknownMinimal manifestation status and prednisone withdrawal in the MGTX trial.
Not available
S-EPMC7455358 | biostudies-literature
UnknownCalculation of ATP production rates using the Seahorse XF Analyzer
Not available
S-SCDT-10_15252-EMBR_202256380 | biostudies-other
ProteomicsRepurposing E3 ubiquitin ligases as cell surface protein degraders using Proteolysis Targeting Antibodies
The majority of current therapeutics targeting plasma membrane receptors function by antagonizing ligand binding or enzymatic activities. Typical mammalian proteins, however, consist of multiple domains executing discrete but coordinated activities, and saturating inhibition of one functional domain...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-05-25 | MSV000089542 | MassIVE
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