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TranscriptomicsEffect of genetic DRYK1B KO
DYRK1B was deleted in a murine PDAC cell line (mKPc4) and assayed for genotype specific changes in gene expression.
ORGANISM(S): Mus musculus 
2024-05-29 | E-MTAB-13666 | biostudies-arrayexpress
TranscriptomicsDYRK1B deletion allograft
Gene expression pattern in s.c. allografted DYRK1BKO-mKpc4 cells
ORGANISM(S): Mus musculus 
2024-05-29 | E-MTAB-13667 | biostudies-arrayexpress
TranscriptomicsMouse bone-marrow-derived macrophages treated with supernatant of DYRK1B-deletion / Wildtype mKpc4 cells
Mus musculus macrophages were derived from bone marrow, and treated with the supernatant of of DYRK1B-deletion (multiple clones) or Wildtype mKpc4 cells.
ORGANISM(S): Mus musculus 
2024-05-29 | E-MTAB-13668 | biostudies-arrayexpress
TranscriptomicsGene expression analysis in lung fibroblasts from p38+/+ (wt) and p38ki/ki (ki) mice
To assess differently expressed genes beween wt and ki fibroblasts Total RNA was purified from fibroblasts of 3 different mice for wt and 3 different mice for ki
ORGANISM(S): Mus musculus 
2016-06-01 | E-GEOD-80825 | biostudies-arrayexpress
ProteomicsExtracellular vesicles from pancreatic cancer cells activate mast cells which in turn promote tumor cell proliferation and establish a tumor-supportive microenvironment
Background and aim: Recent studies reveal a critical role of tumor cell-released extracellular vesicles (EVs) in pancreatic cancer progression. Driver genes directing EV function, the EV-recipient cells, as well as their cellular response to EV uptake remain, however, to be identified. To address th...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-12-06 | MSV000093583 | MassIVE
ProteomicsDYRK1B blockade promotes tumoricidal macrophage activity in pancreatic cancer
Highly malignant pancreatic ductal adenocarcinoma (PDAC) is characterized by an abundant immunosuppressive and fibrotic tumor microenvironment (TME). Future therapeutic attempts therefore demand targeting of both compartments in order to be effective. We show here that Dual Specificity and Tyrosine...
ORGANISM(S): Mus Musculus 
2024-01-02 | MSV000093747 | MassIVE
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