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TranscriptomicsMisregulation of alternative splicing of BIN1 leads to T-tubule alterations and muscle weakness in myotonic dystrophy
Myotonic dystrophes (DM), the most common adult muscular dystrophy, are the first recognized examples of RNA-mediated diseases in which expression of mutant RNAs containing expanded CUG or CCUG repeats interfere with the splicing of other mRNAs. Using whole-genome microarrays, we found that alternat...
ORGANISM(S): Homo sapiens 
2011-05-26 | E-GEOD-21795 | biostudies-arrayexpress
UnknownBridging integrator 1 (Bin1) deficiency in zebrafish results in centronuclear myopathy.
Not available
S-EPMC4049309 | biostudies-literature
UnknownIsoproterenol Promotes Rapid Ryanodine Receptor Movement to Bridging Integrator 1 (BIN1)-Organized Dyads.
Not available
S-EPMC4729615 | biostudies-literature
UnknownBridging Integrator 1 (BIN1) Genotype Effects on Working Memory, Hippocampal Volume, and Functional Connectivity in Young Healthy Individuals.
Not available
S-EPMC4915264 | biostudies-literature
UnknownBridging integrator 1 (BIN1) protein expression increases in the Alzheimer's disease brain and correlates with neurofibrillary tangle pathology.
Not available
S-EPMC4198456 | biostudies-literature
ProteomicsProteomic characterization of the Alzheimer’s disease risk factor BIN1 interactome
The gene BIN1 is the second-largest genetic risk factor for late-onset Alzheimer’s disease (LOAD). BIN1 is expressed in neurons and glia in the brain as multiple isoforms, including neuron-specific and ubiquitously expressed isoforms. BIN1 is an adaptor protein that regulates membrane dynamics in ma...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-22 | PXD060638 | Pride
Phospho proteomics Bridging integrator 1 (bin1) Mouse Late onset alzheimer’s disease (load) Interactome 
UnknownLack of association between bridging integrator 1 (BIN1) rs744373 polymorphism and tau-PET load in cognitively intact older adults.
Not available
S-EPMC8864573 | biostudies-literature
UnknownBridging integrator 1 fragment accelerates tau aggregation and propagation by enhancing clathrin-mediated endocytosis in mice.
Not available
S-EPMC10783739 | biostudies-literature
ProteomicsColonic smooth-muscle BIN1 and ALDH1B1 loss triggers mitochondrial dysfunction and fibrosis in slow-transit constipation
Slow-transit constipation (STC) is a debilitating disorder of colonic motility with poorly defined molecular underpinnings. While abnormalities in the enteric nervous system and interstitial cells of Cajal have been extensively studied, smooth-muscle–intrinsic mechanisms remain largely unexplored. H...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD069723 | Pride
Mitochondrial function  fibrosis  intestinal motility 
UnknownIntracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease.
Not available
S-EPMC4106906 | biostudies-literature
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