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ProteomicsInnate immunocompetent iNSpheroids: A hiPSC-derived 3D model to study the central nervous system captures an early CNS response to rAAV
Gene therapies using adeno-associated viruses (AAVs) for central nervous system (CNS) disorders face challenges due to host immune responses not represented in classical preclinical models. Here, we present a human-induced pluripotent stem cell (hiPSC)-derived innate immunocompetent 3D CNS model tha...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD065639 | Pride
Gene therapy  neuroinflammation  cns models  glial cells 
ProteomicsExoproteomic analysis of two MLST clade 2 strains of Clostridioides difficile from Latin America
Clostridioides difficile BI/NAP1/ribotype 027 is an epidemic hypervirulent strain found worldwide, including in Latin America. We examined the genomes and exoproteomes of two multilocus sequence type (MLST) clade 2 C. difficile strains considered hypervirulent: ICC-45 (ribotype SLO231/UK[CE]821), is...
ORGANISM(S): Clostridioides difficile str. A-027 
2021-07-01 | PXD026218 | Pride
Clostridioides difficile Latin america Mass spectrometry Proteomics Rybotype 
ProteomicsMicroenvironment remodeling during human iPSC-derived NSC 3D differentiation
Brain microenvironment plays an important role in neurodevelopment and function, where extracellular matrix (ECM) components and soluble factors modulate cellular features, as migration, proliferation survival and neuronal function. Disruption of microenvironment’s homeostasis is often related to pa...
ORGANISM(S): Homo sapiens (Human) 
2018-07-31 | PXD007130 | Pride
3d cultures  neual differentiation  hipsc-derived nsc  ecm  microenvironment  swath 
ProteomicsAddressing human astrogliosis in a hiPSC-derived 3D CNS model
Astrogliosis is an inflammatory process by which astrocytes undergo morphological, transcriptional, and functional changes that primarily contribute to tissue healing and restore CNS homeostasis as a response to neuroinflammation. However, excessive astrocyte activation causes neuronal death, immune...
ORGANISM(S): Homo sapiens (Human) 
2025-07-28 | PXD043835 | Pride
Astrogliosis  neuroinflammation  hipsc  3d culture  reactive astrocytes  stirred-tank bioreactors 
UnknownRisk factors for running-related injuries: An umbrella systematic review.
Not available
S-EPMC11336318 | biostudies-literature
UnknownElectrochemical Synthesis of 3-Selenyl-Chromones via Domino C(sp2)-H Bond Selenylation/Annulation of Enaminones.
Not available
S-EPMC12844472 | biostudies-literature
UnknownEffects of calcium supplementation on changes in the IL2, IL4, IL6, IL10 axes and oxidative stress in pregnant women at risk for pre-eclampsia.
Not available
S-EPMC10799391 | biostudies-literature
UnknownPlasmodium simium, a Plasmodium vivax-related malaria parasite: genetic variability of Duffy binding protein II and the Duffy antigen/receptor for chemokines.
Not available
S-EPMC4480967 | biostudies-literature
UnknownExoproteomic analysis of two MLST clade 2 strains of Clostridioides difficile from Latin America reveal close similarities.
Not available
S-EPMC8225638 | biostudies-literature
ProteomicsHuman Cardiac Stem Cells Receptome
Human cardiac stem cells (hCSC) express a portfolio of plasma membrane receptors that are involved in the regulatory auto/paracrine feedback loop mechanism of activation of these cells, and consequently contribute to myocardial regeneration. In order to attain a comprehensive description of hCSC rec...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-01 | MSV000079549 | MassIVE
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