Electrochemical Synthesis of 3-Selenyl-Chromones via Domino C(sp²)-H Bond Selenylation/Annulation of Enaminones.

ABSTRACT: Herein, we disclose a highly efficient pathway toward 3-selenylated chromone derivatives via electrosynthesis domino C(sp²)-H bond selenylation/cyclization/deamination of 2-hydroxyaryl enaminones with diselenides. This method showed mild conditions, easy operation, a wide substrate scope, and good functional group tolerance. Furthermore, this electrosynthesis strategy was amenable to scaling up the reaction. Additionally, the preliminary experiments revealed that this reaction probably proceeded via a cation pathway instead of a radical pathway.

SUBMITTER: Brito JM 

PROVIDER: S-EPMC12844472 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature