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TranscriptomicsTranscription profiling of human MOLT4 cell lines before and after inhibition of gamma secretase to investigate NOTCH signaling in T-cell acute lymphoblastic leukemia cell lines
In T-cell acute lymphoblastic leukemia (T-ALL) NOTCH 1 receptors are frequently mutated. This leads to aberrantly high Notch signaling, but how this translates into deregulated cell cycle control and the transformed cell type is poorly understood. In this report, we analyze downstream responses resu...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6495 | biostudies-arrayexpress
TranscriptomicsIncreased Rho GTPase activity is associated with decreased tumor inhibitory activity of immortalized fibroblasts
Clone (Whirly) of human BJhTERT (human foreskin cell line) cells exposed to PC3 mRFP cells Clones (Whirly) of human BJhTERT (human foreskin cell line) cells exposed to PC3 mRFP cells were analyzed with Affymetrix Whole Target (WT) Assay (GeneTitan plate format Gene ST 1.1)
ORGANISM(S): Homo sapiens 
2014-04-17 | E-GEOD-56832 | biostudies-arrayexpress
TranscriptomicsThe fat cell epigenetic signature in post-obese women is characterized by global hypomethylation and differential DNA methylation of adipogenesis genes
Background/Objectives: Obese subjects have increased number of enlarged fat cells which are reduced in size but not number in post-obesity. We performed DNA methylation profiling in fat cells with the aim of identifying differentially methylated DNA sites (DMS) linked to adipose hyperplasia (many sm...
ORGANISM(S): Homo sapiens 
2015-05-06 | E-GEOD-58622 | biostudies-arrayexpress
TranscriptomicsAffymetrix microarray for gene expression patterns influenced by syndecan-1 overexpression in malignant mesothelioma STAV-AB cells
We aimed to investigate the function of syndecan-1 in tumor cell adhesion and migration, with special focus on the importance of its distinct protein domains, to better understand the structure-function relationship of syndecan-1 in tumor progression. We utilized two mesenchymal tumor cell lines whi...
ORGANISM(S): Homo sapiens 
2010-07-20 | E-GEOD-21401 | biostudies-arrayexpress
TranscriptomicsThe effect of progerin expression on alternative splicing in keratinocytes of HGPS mice
Exon level expression analysis for the HGPS pathological aging study data set to analyze the effect of progerin expression on alternative splicing in keratinocytes of HGPS mice. Analysis of the effect of pathological aging (transgenic progerin expression) on alternative splicing (AS) using exon mic...
ORGANISM(S): Mus musculus 
2015-11-01 | E-GEOD-67288 | biostudies-arrayexpress
TranscriptomicsIncreased Rho GTPase activity is associated with decreased tumor inhibitory activity of immortalized fibroblasts
Two clones (Whirly and Crossy) of human BJhTERT (human foreskin cell line) cells with different inhibitory capacity were analyzed and compared for their gene expression profile by whole genome microarray. Two clones (Whirly and Crossy) of human BJhTERT (human foreskin cell line) cells were analyzed ...
ORGANISM(S): Homo sapiens 
2014-03-08 | E-GEOD-55681 | biostudies-arrayexpress
UnknownSnai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression.
Not available
S-EPMC7299199 | biostudies-literature
TranscriptomicsThe effect of age on alternative splicing in different tissues of wild-type mice
Exon level expression analysis for the physiological aging study data set to analyze the effect of age on alternative splicing in different tissues and age groups of wild-type mice Analysis of the effect of age on alternative splicing (AS) using exon microarrays to interrogate the differential exon ...
ORGANISM(S): Mus musculus 
2015-11-01 | E-GEOD-67287 | biostudies-arrayexpress
TranscriptomicsThe genes regulated by SOX11 in mantle cell lymphoma
The genes regulated by SOX11 in MCL was investigated in MCL cell line Granta 519 by siRNA knock down system. Cells were transfected using the LONZA electroporation system. Results represent cells harvested after 20 hours. Details of the experiment is published in PMID 21124928. Gene expression profi...
ORGANISM(S): Homo sapiens 
2010-11-29 | E-GEOD-25621 | biostudies-arrayexpress
UnknownA new evolutionary scenario for the Mycobacterium tuberculosis complex.
Not available
S-EPMC122584 | biostudies-literature
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