Bromodomain - OmicsDI

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Metabolite Name

Hexenoylcarnitine (Car(6:1)) (1)
4-(Dimethylamino)pyridine (1)
1-Octadecylamine (1)
1-(1Z-Octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine (1)
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Alpinetin (1)
2-Amino-3-methyl-imidazo[4,5-f]quinoline (IQ) (1)
1-(1Z-Octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine (1)
1-O-Hexadecyl-2-O-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glyceryl-3-phosphorylcholine (1)
1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine (1)
1-Docosahexaenoyl-2-stearoyl-sn-glycero-3-phosphocholine (1)
1-O-Hexadecyl-2-O-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glyceryl-3-phosphorylcholine (1)
.beta.-D-Glucopyranosiduronic acid, 4-(7-hydroxy-4-oxo-4H-1-benzopyran-3-yl)phenyl (1)
Dihydrotachysterol (1)
Hispidol (1)
Picoline (1)
Tiglylcarnitine (Car(5:1)) (1)
Cysteine S-sulfate (1)
PC(37:5) (1)
Ethyl 3-aminobenzoate (1)
N-Oleoyl-D-erythro-sphingosylphosphorylcholine (1)

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protozoa (11)
fungi (1)

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Study type

Transcription profiling by array (94)
ChIP-seq (79)
RNA-seq of coding RNA (60)
Other (4)
ChIP-chip by tiling array (3)
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Release Date

2022 (234)
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2023 (185)
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Lab affiliation

Research Unit for Molecular Medicine, Department of clinical Medicine, Aarhus University, Aarhus, Denmark (5)
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (3)
Francis Crick Institute 1 Midland Road London NW1 1AT (2)
Dept. of Molecular Biosciences, University of Texas at Austin, Texas 78712 USA (2)
EDyP (2)
University of Leicester (1)
Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC29425, USA (1)
Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla California 92037 USA (1)
Facutly of Science, University of Geneva (1)
Segal Cancer Proteomics Centre, Lady Davis Institute for Medical Research and Jewish General Hospital, and McGill University, Montréal, Québec, Canada Gerald Bronfman Department of Oncology, McGill University, Montréal, Québec, Canada (1)
Core Unit Proteomics, Berlin Institute of Health at Charite - Universitaetsmedizin Berlin and Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany (1)
EDyP team (1)
School of Life and Environmental Sciences, Charles Perkins Centre, University of Sydney, Australia (1)
Proteomics Program Blegdamsvej 3 2200 København N Bygning 6 Building: 06-2-36 (1)
Department of Molecular, Cellular, & Biomedical Sciences, Chu Lab, University of New Hampshire, United States (1)
Harvard Institutes of Medicine 2nd floor, Room 221 4 Blackfan Circle Boston, MA 02115 (1)
Research Unit for Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark. (1)
Director, Proteomics and Metabolomics Facility, Center for Open Research Resources and Equipment, University of Connecticut, Storrs, CT, USA (1)
Institute for Clinical and Translational Research, University of Wisconsin - Madison (1)
Laboratory of Systems Biology, University of Warsaw (1)
Cardiac Bioengineering group, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia (1)
School of Life Science, Peking University (1)
Laboratory of Cancer Metabolism, Department of Experimental Oncology, Maria Sklodowska-Curie National Research Institute of Oncology (1)
Professor Centre for Targeted Protein Degradation, School of Life Sciences, university of Dundee (1)
Structural and Computational Biology Unit European Molecular Biology Laboratory Meyerhofstr. 1 69117 Heidelberg Germany (1)
Proteomics Unit, Spanish National Cancer Research Centre (CNIO) Melchor Fernández Almagro 3. E28029 MADRID, SPAIN. Phone +34 912246900 ext 3112 (1)
CeMM, Research Center for Molecular Medicine, Austrian Academy of Sciences, Austria (1)
Department of precious medicine, University of Campania "L.Vanvitelli", vico L. de Crecchio 8, Naples, Italy (1)
University of Geneva, Switzerland (1)
1Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA 2Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA 3Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA (1)

Location

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Spain (1)

Keyword

INCB057643 (1)
Azacitidine (1)
Pembrolizumab (1)
CRC (1)
Capecitabine (1)

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Bromodomain-Containing-Protein 4 (BRD4) Regulates RNA Polymerase II Serine 2 Phosphorylation in Human CD4+ T Cells

Transcriptional elongation by RNA polymerase II (Pol II) is regulated by positive transcription elongation factor b (P-TEFb) in association with Bromodomain-containing protein 4 (BRD4). We used genome-wide chromatin immunoprecipitation sequencing in primary human CD4+ T cells to reveal that BRD4 co-...

ORGANISM(S): Homo sapiens

2012-11-14 | E-GEOD-33281 | biostudies-arrayexpress

Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition

Bromodomain inhibition comprises a promising therapeutic strategy in cancer, particularly for hematologic malignancies. To date, however, genomic biomarkers to direct clinical translation have been lacking. We conducted a cell-based screen of genetically-defined cancer cell lines using a prototypica...

ORGANISM(S): Homo sapiens

2013-02-25 | E-GEOD-43392 | biostudies-arrayexpress

The bromodomain protein BRD4 regulates splicing during heat shock

During heat stress cyto-protective genes including heat shock proteins are transcriptionally up-regulated and post-transcriptional splicing is inhibited. In contrast, co-transcriptional mRNA-splicing is maintained. These factors closely resemble the proteotoxic stress response during tumor developme...

ORGANISM(S): Homo sapiens

2016-09-07 | E-GEOD-73471 | biostudies-arrayexpress

Response and resistance to BET bromodomain inhibitors in triple negative breast cancer [ChIP-Seq]

Triple negative breast cancer (TNBC) is a heterogeneous and clinically aggressive disease for which there is no targeted therapy. Here we report the preferential and high sensitivity of TNBCs to BET bromodomain inhibitors such as JQ1 manifested by cell cycle arrest in early G1, apoptosis, and induct...

ORGANISM(S): Homo sapiens

2016-01-07 | E-GEOD-63581 | biostudies-arrayexpress

Response and resistance to BET bromodomain inhibitors in triple negative breast cancer [Chem-Seq]

ORGANISM(S): Homo sapiens

2016-01-07 | E-GEOD-63284 | biostudies-arrayexpress

Response and resistance to BET bromodomain inhibitors in triple negative breast cancer [RNA-Seq]

ORGANISM(S): Homo sapiens

2016-01-07 | E-GEOD-63582 | biostudies-arrayexpress

Therapeutic Targeting of BET Bromodomain Proteins in Castration-Resistant Prostate Cancer (microarray)

Men who develop metastatic castration-resistant prostate cancer (CRPC) invariably succumb to the disease. The development and progression to CRPC following androgen ablation therapy is predominantly driven by unregulated androgen receptor (AR) signaling1-3. Despite the success of recently approved...

ORGANISM(S): Homo sapiens

2014-04-25 | E-GEOD-55063 | biostudies-arrayexpress

Therapeutic Targeting of BET Bromodomain Proteins in Castration-Resistant Prostate Cancer (ChIP-Seq)

ORGANISM(S): Homo sapiens

2014-04-25 | E-GEOD-55062 | biostudies-arrayexpress

Targeting the EWS/ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma

Ewing sarcomas (ES) are highly malignant, osteolytic bone or soft tissue tumors, which are characterized by early metastasis into lung and bone. Genetically, ES are defined by balanced chromosomal EWS/ETS translocations, which give rise to chimeric proteins (EWS-ETS) that generate an oncogenic trans...

ORGANISM(S): Homo sapiens

2015-12-08 | E-GEOD-72673 | biostudies-arrayexpress

Bromodomain-dependent stage-specific male genome programming by Brdt

This SuperSeries is composed of the following subset Series: GSE39908: Bromodomain-dependent stage-specific male genome programming by Brdt [ChIP-Seq] GSE39909: Bromodomain-dependent stage-specific male genome programming by Brdt [Illumina BeadArray] Refer to individual Series

ORGANISM(S): Mus musculus

2012-08-30 | E-GEOD-39910 | biostudies-arrayexpress

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