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TranscriptomicsscRNA-seq analysis of cell subpopulations of the bronchoalveolar lavage fluid of healthy dogs
In dogs, a species for which markers of cell populations are often limiting, we sought to evaluate in an unbiased way the heterogeneity of cell subpopulations in the bronchoalveolar lavage fluid of healthy dogs, by single-cell RNA-sequencing.
ORGANISM(S): Canis lupus familiaris 
2020-06-29 | E-MTAB-9265 | biostudies-arrayexpress
TranscriptomicsIdentification of pro-fibrotic macrophages populations by scRNA-seq in West Highland white terriers affected with canine idiopathic pulmonary fibrosis
We used the scRNA-seq to characterize disease-related heterogeneity within cell populations of macrophages/monocytes in the bronchoalveolar lavage fluid from West Highland white terriers either healthy or affected with canine idioapthic pulmonary fibrosis. The disease is still not well understood, o...
ORGANISM(S): Canis lupus familiaris 
2020-12-02 | E-MTAB-9623 | biostudies-arrayexpress
TranscriptomicsBAL cell gene expression is predictive of Mortality in Idiopathic Pulmonary Fibrosis and enriched for Genes of Airway Basal Cells (I)
Background: Based on previous publication and our own data we became interested in the gene expression signature of airway basal cells. Methods: Bronchoscopy with bronchial brushes and bronchoalveolar lavage was performed in healthy donors. Airway basal cells were obtained by brushing segmental bron...
ORGANISM(S): Homo sapiens 
2018-12-31 | GSE70864 | GEO
TranscriptomicsReal-time quantitative PCR analysis of mRNA from lungs of WT and Pglyrp1-/- mice sensitized with HDM
Wild type (WT) and Pglyrp1-/- mice were treated with PBS or sensitized 5 days/week for 3 or 5 weeks with 10 M-BM-5l per application of 2.5 mg/ml of purified house dust mite allergen. 3 days after the last sensitization the lungs were removed and homogenized, and RNA was isolated from the right lobes...
ORGANISM(S): Mus musculus 
2012-12-25 | E-GEOD-43137 | biostudies-arrayexpress
UnknownHypoxia Exacerbates Inflammatory Acute Lung Injury via the Toll-Like Receptor 4 Signaling Pathway.
Not available
S-EPMC6064949 | biostudies-literature
UnknownDiagnosis and prognosis of acute respiratory distress syndrome related to diffuse pneumonic-type adenocarcinoma: a single-center case series study.
Not available
S-EPMC9442528 | biostudies-literature
Proteomicsvaccination protects against COVID-associated pulmonary fibrin deposition
Our recent work showed COVID BALF from vaccinated individuals contained significantly lower concentration of fibrinogen and prothrombin, suggesting a potential benefit of vaccination being lower risk of fibrin clotting and acute lung injury. As our previous mass spec-based proteomic ID approach show...
ORGANISM(S): Homo sapiens (Human) 
2025-10-06 | PXD066557 | Pride
Fibrin clotting Bal Covid Pulmonary disease Bronchi alveolar lavage Sars-covid-2 
UnknownGlutathione ethyl ester supplementation prevents airway hyper-responsiveness in mice.
Not available
S-EPMC7729341 | biostudies-literature
TranscriptomicsmRNA expression data from lung (left lobe only) dissected from either wild-type mice or Scnn1b-transgenic mice at post-natal days 0, 3, 10, and 42.
Scnn1b-Tg mice overexpress the beta subunit of the epithelial sodium channel (Scnn1b) in airway Club cells. The general phenotype of these mice is described in three published manuscripts (Mall et al. 2004, Nature Medicine, 10(5):487-93; Mall et al. 2008, Am J Respir Crit Care Med. 177(7):730-42; ...
ORGANISM(S): Mus musculus 
2014-09-11 | E-GEOD-47546 | biostudies-arrayexpress
MetabolomicsMass spectrometry imaging of phosphatidylcholine metabolism in lungs administered with therapeutic surfactants and isotopic tracers

Mass spectrometry imaging (MSI) visualises molecular distributions throughout tissues but is blind to dynamic metabolic processes. Here, MSI with high mass resolution together with multiple stable isotope labelling provided spatial analyses of phosphatidylcholine (PC) metabolism in mouse lungs. D...

2020-10-30 | MTBLS2075 | MetaboLights
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