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GenomicsChIPseq examination of EAP-1 binding across generations of spr-5(by101) mutant worms
How epigenetic information is transmitted from generation to generation remains largely unknown. Deletion of the C. elegans Histone H3 lysine 4 dimethyl (H3K4me2) demethylase spr-5 leads to inherited accumulation of the euchromatic H3K4me2 mark and progressive decline in fertility. Here we identifie...
ORGANISM(S): Caenorhabditis elegans 
2014-04-08 | E-GEOD-52102 | biostudies-arrayexpress
GenomicsPolycomb associates genome-wide with a specific RNA polymerase II variant, and regulates metabolic genes in ES cells (ChIP-Seq)
Polycomb repressor complexes (PRCs) are important chromatin modifiers fundamentally implicated in pluripotency and cancer. Polycomb silencing in embryonic stem cells (ESCs) can be accompanied by active chromatin and primed RNA polymerase II (RNAPII), but the relationship between PRCs and RNAPII rema...
ORGANISM(S): Mus musculus 
2012-02-01 | E-GEOD-34518 | biostudies-arrayexpress
TranscriptomicsRNA-Seq in neurons from E16.5 mouse embryonic cortices from WT and SMCX KO mice
We conducted RNA-Seq (using Direct Ligation of Adapters to first strand cDNA) in neurons from E16.5 mouse embryonic cortices from WT and SMCX KO mice and harvested after 10 days in vitro culture. We sequenced RNA samples after 10 days in vitro cultures in biological and technical duplicates. 4 RNA s...
ORGANISM(S): Mus musculus 
2016-01-27 | E-GEOD-61024 | biostudies-arrayexpress
GenomicsChIP-Seq of H3K4 methylation in neurons isolated from E16.5 mouse embryonic cortices from WT and SMCX KO mice
We conducted ChIP-Seq of H3K4 methylation in neurons isolated from E16.5 mouse embryonic cortices from WT and SMCX KO mice and harvested after 10 days in vitro culture. We sequenced H3K4me1, H3K4me3 ChIP and Input samples from mouse embryonic cortical neurons cultured in vitro for 10 days. Experimen...
ORGANISM(S): Mus musculus 
2016-01-27 | E-GEOD-61023 | biostudies-arrayexpress
TranscriptomicsKDM5C safeguards the appropriate timing of early neurodevelopment
We generated human induced pluripotent cells from intellectual disability patients carrying the c.2T>C mutation in KDM5C (Called “Mutant”). We generated a paired, isogenic human iPS cell line (called “Corrected”) using CRISPR/Cas9 and PiggyBac gene-editing technologies and conducted neuronal differe...
ORGANISM(S): Homo sapiens 
2023-10-13 | E-MTAB-7551 | biostudies-arrayexpress
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