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UnknownThe pspC gene of Streptococcus pneumoniae encodes a polymorphic protein, PspC, which elicits cross-reactive antibodies to PspA and provides immunity to pneumococcal bacteremia.
PspC is one of three designations for a pneumococcal surface protein whose gene is present in approximately 75% of all Streptococcus pneumoniae strains. Under the name SpsA, the protein has been shown to bind secretory immunoglobulin A (S. Hammerschmidt, S. R. Talay, P. Brandtzaeg, and G. S. Chhatwa...
S-EPMC97064 | biostudies-literature
UnknownPlasminogen activator inhibitor 1 is associated with high-grade serous ovarian cancer metastasis and is reduced in patients who have received neoadjuvant chemotherapy.
Introduction: High-grade serous ovarian cancer (HGSOC) is the most prevalent and deadliest subtype of epithelial ovarian cancer (EOC), killing over 140,000 people annually. Morbidity and mortality are compounded by a lack of screening methods, and recurrence is common. Plasminogen-activator-i...
S-EPMC10740207 | biostudies-literature
UnknownMAS NMR Investigation of Molecular Order in an Ionic Liquid Crystal.
The structure and molecular order in the thermotropic ionic liquid crystal (ILC), [choline][geranate(H)octanoate], an analogue of Choline And GEranate (CAGE), which has potential for use as a broad-spectrum antimicrobial and transdermal and oral delivery agent, were investigated by magic-angle spinn...
S-EPMC7341529 | biostudies-literature
UnknownThrombopoietin mimetic therapy alleviates radiation-induced bone marrow vascular injury in a bone marrow transplant mouse model.

Background

There is a need for therapies that can mitigate bone marrow dysfunction and organ toxicity that occur following myeloablative injury and reduced intensity conditioning regimens used in patients undergoing bone marrow transplantation (BMT). The pathogenesis of adverse effects from ...
S-EPMC11499237 | biostudies-literature
UnknownA mosaic tetracycline resistance gene tet(S/M) detected in an MDR pneumococcal CC230 lineage that underwent capsular switching in South Africa.

Objectives

We reported tet(S/M) in Streptococcus pneumoniae and investigated its temporal spread in relation to nationwide clinical interventions.

Methods

We whole-genome sequenced 12 254 pneumococcal isolates from 29 countries on an Illumina HiSeq sequencer. Serotype, multilocus ST a...
S-EPMC7021099 | biostudies-literature
UnknownEvidence of a genetic link between endometriosis and ovarian cancer.

Objective

To evaluate whether endometriosis-associated genetic variation affects risk of ovarian cancer.

Design

Pooled genetic analysis.

Setting

University hospital.

Patient(s)

Genetic data from 46,176 participants (15,361 ovarian cancer cases and 30,815 controls) from 4...
S-EPMC5068352 | biostudies-literature
UnknownAdjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial.

Background

Staphylococcus aureus bacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampicin would reduce bacteriologically confirmed treatment failure or disease recurrence, or death, by enhancing ...
S-EPMC5820409 | biostudies-literature
UnknownFive-year exposure to PM2.5 and ozone and subclinical atherosclerosis in late midlife women: The Study of Women's Health Across the Nation.

Introduction

Effects of more than one-year exposure to air pollution on atherosclerosis is seldom studied. This paper aims to examine the association between five-year exposure to particulate matter ≤2.5 μm (PM2.5), ozone (O3) and atherosclerosis observed about seven ye...
S-EPMC6408975 | biostudies-literature
GenomicsPPARG regulated genes in the day 14 ovine conceptus
PPARG ChIP seq analysis was conducted to determine genes bound by and potentially regulated by PPARG in the developing ovine conceptus. Determination of gene regulation by prostaglandins through PPARG helps to improve our understanding of early pregnancy events and provides a basis for strategies to...
ORGANISM(S): Ovis aries 
2014-07-03 | E-GEOD-59011 | biostudies-arrayexpress
UnknownThe role of interspecies recombination in the evolution of antibiotic-resistant pneumococci.
Multidrug-resistant Streptococcus pneumoniae emerge through the modification of core genome loci by interspecies homologous recombinations, and acquisition of gene cassettes. Both occurred in the otherwise contrasting histories of the antibiotic-resistant S. pneumoniae lineages PMEN3 a...
S-EPMC8321556 | biostudies-literature
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