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GenomicsGenome-wide mutation analysis of germinal-center B-cell derived lymphomas within the ICGC MMML-Seq Consortium
Germinal-center B-cell derived lymphomas (GCB-lymphomas) are the most common B-cell lymphomas in children and adults, with Burkitt Lymphomas (BL) predominating in childhood and follicular lymphoma (FL) and diffuse large B-cell lymphomas (DLBCL) predominating in older age groups. The cell-of-origin i...
EGAS00001000394 | EGA
TranscriptomicsPromiscuous gene expression in human medullary thymic epithelial cell subsets
Different human mTEC subsets (MUC1, CEACAM5 and SGLT1) were purified by sequential enzymatic digestion (collagenase/dispase, trypsin) followed by enrichment using magnetic beads (CD45 beads, Miltenyi Biotech) and FACS sorting. Cells of the surface phenotype CD45-, CDR2-, EpCAM+ were further subdiv...
ORGANISM(S): Homo sapiens 
2013-08-31 | E-GEOD-49625 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type and sigma B mutant Liseteria monocytogenes to characterise the EGD-e sigma B regulon
Briefly, over night cultures of L. monocytogenes EGD-e cells (wild-type and sigma B mutant) were grown in brain heart infusion (BHI) broth (Difco). Bacteria were diluted 1:50 in 20 ml fresh BHI and incubated using a 100 ml Erlenmeyer flask at 37 °C with shaking (180 rpm, Unitron [Infors]). Bacterial...
ORGANISM(S): Listeria monocytogenes 
2008-07-02 | E-MEXP-1170 | biostudies-arrayexpress
UnknownDNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia.
Not available
S-EPMC4963005 | biostudies-literature
GenomicsGenome-wide identification of distinct miRNA-mRNA target regulation pairs in Non-Hodgkin lymphomas: a report from the ICGC MMML-Seq consortium
We obtained miRNA profiles by miRnome sequencing from ICGC MMML-Seq patients diagnosed with Burkitt lymphoma, diffuse large B-cell lymphoma and follicular lymphoma and provide evidence of subtype-specific miRNA expression differences. We describe differentially expressed, mutated, edited and not pre...
EGAS00001001394 | EGA
UnknownAlterations of microRNA and microRNA-regulated messenger RNA expression in germinal center B-cell lymphomas determined by integrative sequencing analysis.
Not available
S-EPMC5394868 | biostudies-literature
TranscriptomicsLinking aberrant chromatin features in chronic lymphocytic leukemia to deregulated transcription factor networks
In chronic lymphocytic leukemia (CLL) a diverse set of genetic mutations is embedded in a deregulated epigenetic landscape that drives cancerogenesis. To elucidate the role of aberrant chromatin features, we mapped DNA methylation, 7 histone modifications, nucleosome positions, chromatin accessibili...
ORGANISM(S): Homo sapiens 
2019-05-22 | GSE113336 | GEO
UnknownCorrespondence analysis applied to microarray data.
Not available
S-EPMC58552 | biostudies-literature
TranscriptomicsMAQC 2 color
This set of profiles was utilized to construct, validate and evaluate a gene-expression based classifier of outcome of neuroblastoma patients
ORGANISM(S): Homo sapiens 
2010-11-01 | E-MTAB-161 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of purified human CD34+ cells from patients treated with imatinib, and those from healthy donors
purified CD34+ cells from bone marrow of imatinib-treated patients were compared to those of healthy donors
ORGANISM(S): Homo sapiens 
2007-07-29 | E-GEOD-1418 | biostudies-arrayexpress
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