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TranscriptomicsTranscription profiling of mouse thymic stromal cells from 6-12 week old wild type (C57BL/6) and Aire knock-outs (mixed background)
Gene expression in different thymic stromal cells and subsets thereof was analyzed in 6-12 week old wild type (C57BL/6) and Aire knock-out (mixed background) mice. Thymic stromal cells were purified by sequential enzymatic digestion (collagenase, collagenase/dispase and trypsin) followed by gradient...
ORGANISM(S): Mus musculus 
2007-12-15 | E-GEOD-2585 | biostudies-arrayexpress
TranscriptomicsAutotaxin is expressed in FLT3-ITD positive acute myeloid leukemia and hematopoietic stem cells and promotes cell migration and proliferation
Autotaxin (ATX) has been reported to act as a motility and growth factor in a variety of cancer cells. The ATX protein acts as a secreted lysophospholipase D (lysoPLD) by converting lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA), which signals via G-protein coupled receptors and has im...
ORGANISM(S): Homo sapiens 
2013-05-10 | E-MTAB-1169 | biostudies-arrayexpress
TranscriptomicsMicroarray Quality Control Study 2, Neuroblastoma one-color
This set of profiles was utilized to construct, validate and evaluate a gene-expression based classifier of outcome of neuroblastoma patients
ORGANISM(S): Homo sapiens 
2010-12-31 | E-MTAB-179 | biostudies-arrayexpress
TranscriptomicsPromiscuous gene expression in human medullary thymic epithelial cell subsets
Different human mTEC subsets (MUC1, CEACAM5 and SGLT1) were purified by sequential enzymatic digestion (collagenase/dispase, trypsin) followed by enrichment using magnetic beads (CD45 beads, Miltenyi Biotech) and FACS sorting. Cells of the surface phenotype CD45-, CDR2-, EpCAM+ were further subdiv...
ORGANISM(S): Homo sapiens 
2013-08-31 | E-GEOD-49625 | biostudies-arrayexpress
TranscriptomicsMAQC 2 color
This set of profiles was utilized to construct, validate and evaluate a gene-expression based classifier of outcome of neuroblastoma patients
ORGANISM(S): Homo sapiens 
2010-11-01 | E-MTAB-161 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of purified human CD34+ cells from patients treated with imatinib, and those from healthy donors
purified CD34+ cells from bone marrow of imatinib-treated patients were compared to those of healthy donors
ORGANISM(S): Homo sapiens 
2007-07-29 | E-GEOD-1418 | biostudies-arrayexpress
TranscriptomicsComparison of expression profiles of breast tumors with or without presence of disseminated tumor cells
We used here the presence of disseminated tumors cells (DTC) in the bone marrow for defining early metastasized breast cancer patients. By comparing expression profiles of early metastasized primary breast tumors with non-metastasized tumors, we found candidate metastasis suppressor genes that were ...
ORGANISM(S): Homo sapiens 
2015-04-01 | E-MTAB-2501 | biostudies-arrayexpress
GenomicsGenome-wide mutation analysis of germinal-center B-cell derived lymphomas within the ICGC MMML-Seq Consortium
Germinal-center B-cell derived lymphomas (GCB-lymphomas) are the most common B-cell lymphomas in children and adults, with Burkitt Lymphomas (BL) predominating in childhood and follicular lymphoma (FL) and diffuse large B-cell lymphomas (DLBCL) predominating in older age groups. The cell-of-origin i...
EGAS00001000394 | EGA
TranscriptomicsRAI2 overexpression in MDA-MB231
MDA-MB231 cells were transfected with control vector, RAI2-overexpression vector, or vector with RAI2-4A, which has a mutated interaction domain w.r.t. CtBP/CtBP2 Three replicates each of control condition, RAI2 overexpression or RAI2-4A overexpression.
ORGANISM(S): Homo sapiens 
2015-06-15 | E-GEOD-65489 | biostudies-arrayexpress
TranscriptomicsComparative transcriptome profiling of Amyloid Precursor Protein APP family members in the adult cortex
The β-amyloid precursor protein APP and the related APLPs, undergo complex proteolytic processing giving rise to several fragments. Whereas it is well established that Aβ accumulation is a central trigger for Alzheimer disease (AD), the physiological role of APP family members and their diverse pr...
ORGANISM(S): Mus musculus 
2011-03-18 | E-GEOD-25926 | biostudies-arrayexpress
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