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TranscriptomicsIntermittent neonatal hypoxia elicits the upregulation of inflammatory-related genes in the adult rat through long-lasting programming effects
The long-term effects of neonatal intermittent hypoxia (IH), an accepted model of apnea-induced hypoxia, are unclear. We have previously shown lasting “programming” effects on the HPA axis in adult rats exposed to neonatal IH. We hypothesized that neonatal rat exposure to IH will subsequently re...
ORGANISM(S): Rattus norvegicus 
2016-01-07 | E-GEOD-74145 | biostudies-arrayexpress
TranscriptomicsSmooth Muscle Cells
This set contains 68 arrays of two series of experiments. 60 arrays are used to profile the heterogeneity of SMCs from different anatomic locations. 8 arrays are used to profile the change of gene expression of vascular smooth muscle cells upon serum exposure. An all pairs experiment design type is ...
ORGANISM(S): Homo sapiens 
2007-09-27 | E-GEOD-7195 | biostudies-arrayexpress
TranscriptomicsAnalysis of gene expression profiles from the liver of rats treated with the mitochondrial electron transport chain complex III inhibitor GSK932121A (50mg/kg) or vehicle control
BACKGROUND: Correlating in vitro mitochondrial data to outcomes in vivo remains a challenge and improving methods to assess mitochondrial function in vivo would both guide safer candidate selection and support the growing number of discovery programmes targeting mitochondria for pharmacological inte...
ORGANISM(S): Rattus norvegicus 
2015-01-29 | E-GEOD-65374 | biostudies-arrayexpress
TranscriptomicsRNA-seq of whole lungs from Irgm1-/- and wildtype littermates mice that were either uninfected or infected with influenza for 3, 6, or 10 days
We found that a dose of influenza (5,000 pfu of recombinant influenza A/WSN/33 (rWSN) H1N1 virus strain) that resulted in 50% mortality in wildtype littermate control mice showed minimal mortality in Irgm1-/- mice, indicating that Irgm1 deficiency was protective during influenza infection. This prot...
ORGANISM(S): Mus musculus 
2017-08-08 | E-MTAB-5337 | biostudies-arrayexpress
TranscriptomicsCaloric restriction induces heat shock response and inhibits B16F10 cell tumorigenesis both in vitro and in vivo
Caloric restriction (CR) without malnutrition is one of the most consistent strategies for increasing mean and maximal lifespan and delaying the onset of age-associated diseases. Stress resistance is a common trait of many long-lived mutants and life-extending interventions, including CR. Indeed, be...
ORGANISM(S): Mus musculus 
2015-08-06 | E-GEOD-67430 | biostudies-arrayexpress
TranscriptomicsNanoString analysis of a rat liver mRNA panel following TCDD treatment
Profiling of mRNA abundances with high-throughput platforms such as microarrays and RNA-Seq has become an important tool in both basic and biomedical research. However these platforms remain prone to systematic errors, and have challenges in clinical and industrial application. As a result it is sta...
ORGANISM(S): Rattus norvegicus 
2013-12-31 | E-GEOD-43251 | biostudies-arrayexpress
TranscriptomicsCandidate genes for alcohol preference in alcohol-preferring and non-preferring reciprocal congenic rats
The goal of this study was to identify candidate genes that may influence alcohol consumption by comparing gene expression in 5 brain regions of alcohol-naïve iP and P.NP rats. Background: Selectively bred P (alcohol preferring) and NP (alcohol non-preferring) rats differ greatly in alcohol prefere...
ORGANISM(S): Rattus norvegicus 
2009-12-30 | E-GEOD-15415 | biostudies-arrayexpress
UnknownDefining patient outcomes in stage IV colorectal cancer: a prospective study with baseline stratification according to disease resectability status.
Not available
S-EPMC2816665 | biostudies-literature
TranscriptomicsSystematic Evaluation of Medium-Throughput mRNA Abundance Platforms
Profiling of mRNA abundances with high-throughput platforms such as microarrays and RNA-Seq has become an important tool in both basic and biomedical research. However these platforms remain prone to systematic errors, and have challenges in clinical and industrial application. As a result it is sta...
ORGANISM(S): Rattus norvegicus 
2012-10-18 | E-GEOD-41388 | biostudies-arrayexpress
UnknownSupported exercise TrAining for Men wIth prostate caNcer on Androgen deprivation therapy (STAMINA): study protocol for a randomised controlled trial of the clinical and cost-effectiveness of the STAMINA lifestyle intervention compared with optimised usual care, including internal pilot and parallel process evaluation.
Not available
S-EPMC11010375 | biostudies-literature
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