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MetabolomicsEnergy-stress-mediated AMPK activation inhibits ferroptosis

Energy stress depletes ATP and induces cell death. Here we identify an unexpected inhibitory role of energy stress on ferroptosis, a form of regulated cell death induced by iron-dependent lipid peroxidation. We found that ferroptotic cell death and lipid peroxidation can be inhibited by treatment...

2023-01-31 | MTBLS1399 | MetaboLights
MetabolomicsImidazole ketone erastin induces ferroptosis and slows tumor growth in a mouse lymphoma model
Ferroptosis is a form of regulated cell death that can be induced by inhibition of the cystine-glutamate antiporter, system xc-. Among the existing system xc- inhibitors, imidazole ketone erastin (IKE) is a potent, metabolically stable inhibitor of system xc- and inducer of ferroptosis potentially s...
2019-04-17 | MTBLS774 | MetaboLights
TranscriptomicsTranscription profiling of Salmonella enterica serovar Typhimurium definitive phage type 104 (DT104) isolates
Salmonella enterica serovar Typhimurium (S. Typhimurium) definitive phage type 104 (DT104) has caused significant morbidity and mortality in humans and animals for almost three decades. We have completed the full DNA sequence of one DT104 strain, NCTC13348 and show that the main differences between ...
ORGANISM(S): Salmonella enterica 
2008-09-05 | E-MTAB-20 | biostudies-arrayexpress
TranscriptomicsThe effect of GW3965 and dexamethasone on gene expression of rat livers
GLUCOCORTICOIDS are steroid hormones that strongly influence intermediary carbohydrate metabolism by increasing the transcription rate of glucose-6-phosphatase (G6Pase) a key enzyme of gluconeogenesis, and suppress the immune system which makes them one of the most important therapeutic agents in th...
ORGANISM(S): Rattus norvegicus 
2012-04-01 | E-GEOD-29912 | biostudies-arrayexpress
TranscriptomicsDm_y[1]cn[1] bw[1] sp[1]_pupa_WhitePrePupaep2days_TotalRNA_p200_344-346-348_38bp
modENCODE_submission_541 This submission comes from a modENCODE project of Susan Celniker. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We will generate over 600 RNA samples in biological triplicate and use them to generate expression profile maps detailing t...
ORGANISM(S): Drosophila melanogaster 
2010-08-04 | E-GEOD-23223 | biostudies-arrayexpress
TranscriptomicsDm_y[1]cn[1] bw[1] sp[1]_embryo_4-6h_poly-Ap_p200_409-410-411_38bp
modENCODE_submission_121 This submission comes from a modENCODE project of Susan Celniker. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We will generate over 600 RNA samples in biological triplicate and use them to generate expression profile maps detailing t...
ORGANISM(S): Drosophila melanogaster 
2010-08-04 | E-GEOD-23219 | biostudies-arrayexpress
TranscriptomicsDm_y[1]cn[1] bw[1] sp[1]_embryo_6-8h_TotalRNA_p200_230-232_38bp
modENCODE_submission_763 This submission comes from a modENCODE project of Susan Celniker. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We will generate over 600 RNA samples in biological triplicate and use them to generate expression profile maps detailing t...
ORGANISM(S): Drosophila melanogaster 
2010-08-04 | E-GEOD-23230 | biostudies-arrayexpress
TranscriptomicsmRNA-Seq of whole flies from Drosophila
We sequenced mRNA from whole flies of females and male of Drosophila melanogaster, D. simulans, D. yakuba, D. ananassae, D. pseudobscura, D. mojavensis, and D. virilis as part of the modENCODE project to validate novel gene models found in D. melanogaster, identify genes differentially expressed bet...
ORGANISM(S): Drosophila melanogaster 
2011-03-23 | E-GEOD-28078 | biostudies-arrayexpress
UnknownAmyotrophic lateral sclerosis: an emerging era of collaborative gene discovery.
Not available
S-EPMC2100166 | biostudies-literature
UnknownAn integrated encyclopedia of DNA elements in the human genome.
Not available
S-EPMC3439153 | biostudies-literature
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