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MetabolomicsAbsence of MCJ/DnaJC15 promotes brown adipose tissue thermogenesis
Obesity poses a global health challenge, demanding a deeper understanding of adipose tissue (AT) and its mitochondria. This study describes the role of the mitochondrial protein Methylation-controlled J protein (MCJ/DnaJC15) in orchestrating brown adipose tissue (BAT) thermogenesis. Here we show how...
2024-10-31 | MTBLS11505 | MetaboLights
TranscriptomicsMouse brown adipocyte single nucleus RNAseq with Smartseq2
Mouse brown adipocyte single nucleus RNAseq with Smartseq2
ORGANISM(S): Mus musculus 
2020-07-13 | E-MTAB-8561 | biostudies-arrayexpress
ProteomicsRat Bronchoalveolar Lavage Proteome Changes Following E-cigarette Aerosol Exposures
Label free quantitative proteomics of bronchoalveolar lavage (BAL) fluid collected from rats exposed to e-cigarette aerosols (humidified air control, PG/VG, PG/VG + Nicotine, or PG/VG + Nicotine + Vanillin)
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2023-01-06 | MSV000091015 | MassIVE
TranscriptomicsSingle nucleus RNA sequencing in mouse brown adipose tissue at room temperature, cold condition and thermoneutrality
Single nucleus RNA sequencing in mouse brown adipose tissue at room temperature, cold condition and thermoneutrality.
ORGANISM(S): Mus musculus 
2020-07-13 | E-MTAB-8562 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver from wild-type (129S1/SvImJ) and PPARalpha-null (129S4/SvJae) animals treated with WY14643 vs. controls - 3
PPARα is a ligand-activated transcription factor involved in the regulation of nutrient metabolism and inflammation. Although much is already known about the function of PPARα in hepatic lipid metabolism, many PPARα-dependent pathways and genes have yet to be discovered. In order to obtain an ov...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8292 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat livers with inactivated PPARI
PPARα is a ligand-activated transcription factor involved in the regulation of nutrient metabolism and inflammation. Although much is already known about the function of PPARα in hepatic lipid metabolism, many PPARα-dependent pathways and genes have yet to be discovered. In order to obtain an ov...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8302 | biostudies-arrayexpress
MetabolomicsJ-Resolved 1H NMR 1D-Projections for Large-Scale Metabolic Phenotyping Studies: Application to Blood Plasma Analysis
1H nuclear magnetic resonance (NMR) spectroscopy-based metabolic phenotyping is now widely used for large-scale epidemiological applications. To minimize signal overlap present in 1D 1H NMR spectra, we have investigated the use of 2D J-resolved (JRES) 1H NMR spectroscopy for large-scale phenotyping ...
2018-07-23 | MTBLS540 | MetaboLights
TranscriptomicsC-peptide regulates early transcription in rat proximal tubular cells
C-peptide exerts beneficial effects on glomerular hyperfiltration in type I diabetic patients. As C-peptide localizes to the nucleus, we investigated the transcriptional activities of C-peptide in proximal tubular cells isolated from diabetic rats. Two groups of proximal tubular cells isolated from ...
ORGANISM(S): Rattus norvegicus 
2011-07-26 | E-GEOD-24687 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver wild type and PPARI?-nulls -1
PPARα is a ligand-activated transcription factor involved in the regulation of nutrient metabolism and inflammation. Although much is already known about the function of PPARα in hepatic lipid metabolism, many PPARα-dependent pathways and genes have yet to be discovered. In order to obtain an ov...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8290 | biostudies-arrayexpress
TranscriptomicsGenetic Influences on Asthma Susceptibility in Developing Lung
Whole transcriptome assay of whole lung of rat from 3 genetic strains (Lewis, Fisher, Brown Norway) at 3 postnatal time points (postnatal days 1, 7, 14). Total RNA obtained from whole lung of rat from 3 genetic strains and 3 postnatal time points in (mainly) quadruplicate measurements per strain and...
ORGANISM(S): Rattus norvegicus 
2010-06-24 | E-GEOD-19666 | biostudies-arrayexpress
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