Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
1H nuclear magnetic resonance (NMR) spectroscopy-based metabolic phenotyping is now widely used for large-scale epidemiological applications. To minimize signal overlap present in 1D 1H NMR spectra, we have investigated the use of 2D J-resolved (JRES) 1H NMR spectroscopy for large-scale phenotyping ...
Brown adipose tissue eject vesicles containing mitochondria proteins to maintain energy homeostasis. Here the quantitative proteomics identified the protein cargo of MDVs.
Examination of gene expression associated with hypoxia treatment of parental Fawn Hooded Hypertensive (FHH) and consomic Brown Norway (FHH1BN) rat strain. FHH1BN rats are derived from introgression of chromosome 1 from BN rats into the FHH genetic background.
Examination of gene expression associated with hypoxia treatment of parental salt sensitive (SS) and consomic Brown Norway (SSYBN) rat strain. SSYBN rats are derived from introgression of chromosome Y from BN rats into the SS genetic background.
Adipose tissue functions in terms of energy homeostasis as a rheostat for blood triglyceride, regulating its concentration, in response to external stimuli. In addition it acts as a barometer to inform the central nervous system of energy levels which can vary dramatically between meals and accor...
Examination of gene expression associated with hypoxia treatment of parental salt sensitive (SS) and consomic Brown Norway (SS9BN) rat strain. SS9BN rats are derived from introgression of chromosome 9 from BN rats into the SS genetic background.
Examination of gene expression changes during hypoxia of the Fawn Hooded Hypertensive (FHH) rat and FHH12BN consomic rat. FHH12BN rats are derived from introgression of chromosome 12 and from the Brown Norway (BN) rat into the FHH genetic background.
Examination of gene expression changes during hypoxia of the Dahl salt sensative (SS) rat and SS4BN consomic rat. SS4BN rats are derived from introgression of chromosome 4 from Brown Norway (BN) rat into the genetic background.
Examination of gene expression changes during hypoxia of the Dahl salt sensative (SS) rat and SS11BN consomic rat. SS11BN rats are derived from introgression of chromosome 11 from Brown Norway (BN) rat into the SS genetic background.
