Brown Laura C LC

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Unknown (14)
Metabolomics (4)
Transcriptomics (1)
Proteomics (1)

Organisms

Rattus norvegicus (1)

Repository

MetaboLights (3)
biostudies-arrayexpress (1)
GNPS (1)
MassIVE (1)

Technology Type

Mass spectrometry (3)

Instrument Platform

Agilent 6530 QTOF (2)
Q Exactive (1)
Liquid Chromatography MS - positive (1)
Liquid Chromatography MS - positive - reverse phase (1)
Liquid Chromatography MS - negative - reverse phase (1)

Publication Date

2020 (2)
2015 (1)
2024 (1)
2023 (1)
2021 (1)

CHEBI ID

CHEBI:30754 (3)
CHEBI:27823 (3)
CHEBI:27897 (3)
CHEBI:18344 (3)
CHEBI:137228 (2)
CHEBI:46171 (2)
CHEBI:17752 (2)
CHEBI:67249 (2)
CHEBI:40410 (2)
CHEBI:16742 (2)
CHEBI:16610 (2)
CHEBI:40992 (2)
CHEBI:169985 (2)
CHEBI:37084 (2)
CHEBI:50129 (2)
CHEBI:28747 (2)
CHEBI:15918 (2)
CHEBI:18300 (2)
CHEBI:17084 (2)
CHEBI:17154 (2)
CHEBI:16675 (2)
CHEBI:28683 (2)
CHEBI:16958 (2)
CHEBI:27266 (2)
CHEBI:16811 (2)
CHEBI:73705 (2)
CHEBI:28790 (2)
CHEBI:16040 (2)
CHEBI:2274 (2)
CHEBI:18095 (2)

Metabolite Name

Serotonin (2)
Kynurenine (2)
Tryptophan (2)
Octadecanoicacid (1)
Perfluoroctanoic acid (PFOA) (1)
Hexadecanoicacid (1)
2-(Acetylamino)hexanoic acid (1)
Xylenesulfonate (1)
N1-(4-butyl-2-methylphenyl)-2-(benzylamino)-2-thioxoacetamide (1)
1,4-Lactone (1)
2-Hydroxy glutaric acid (1)
Benazol P (1)
(1R,3R,4S,5R)-3,4-bis({[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy})-1,5-dihydroxycyclohexane-1-carboxylic acid (1)
2-Heptyl-4-hydroxyquinoline-N-oxide (1)
(6Z)-Octadecenoicacid (1)
2-({2-[4-(4-Fluorophenyl)piperazino]-2-oxoethyl}sulfanyl)acetic acid (1)
3-Desoxy-3,4-methylenedioxy pyrovalerone (1)
3,5-di-tert-Butyl-4-hydroxybenzaldehyde (1)
(+/-)-threo-Methylnaphthidate (1)
6-(2-chloroanilino)-4-oxo-2-(4-pyridyl)-3,4-dihydro-2H-1,3-thiazine-5-carbonitrile (1)
2-(4-Methoxybenzylidene)quinuclidin-3-one (1)
2-benzyl-6-hydroxy-2-azabicyclo[2.2.2]octan-3-one (1)
N1-bicyclo[2.2.2]oct-2-ylbenzamide (1)
1-(Benzylamino)-3-(3,4-dimethylphenoxy)propan-2-ol (1)
Imidazosagatriazinone (1)
2-Hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone (1)
4-(2-hydroxyphenyl)-8,9-dimethyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one (1)
Phenazine-2-carboxylic acid (1)
1-(1,3,3-Trimethyl-2,3-dihydro-1H-indol-2-yliden)acetone (1)
5-(2-Thienyl)nicotinic acid (1)

Study type

Transcription profiling by array (1)

Release Date

2023 (3)
2022 (3)
2025 (2)
2021 (2)
2011 (2)
2015 (1)
2024 (1)
2013 (1)

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Effect of Genetically Reduced Maternal Myostatin on Late Gestation Maternal, Fetal, and Placental Metabolomes in Mice.

Myostatin (gene symbol: Mstn) is an autocrine and paracrine inhibitor of muscle growth. Pregnant mice with genetically reduced levels of myostatin give birth to offspring with greater adult muscle mass and bone biomechanical strength. However, maternal myostatin is not detectable in fetal cir...

2023-06-08 | MTBLS3345 | MetaboLights

Untargeted metabolomics reveals species-specific metabolite production and shared nutrient consumption by Pseudomonas aeruginosa and Staphylococcus aureus

While bacterial metabolism is known to impact antibiotic efficacy and virulence, the metabolic capacities of individual microbes in cystic fibrosis lung infections are difficult to disentangle from sputum samples. Here, we show that untargeted metabolomic profiling of supernatants of multiple str...

2021-05-26 | MTBLS2105 | MetaboLights

Association between altered tryptophan metabolism, plasma aryl hydrocarbon receptor agonists, and inflammatory Chagas disease

Chagas disease causes a cardiac illness characterized by immunoinflammatory reactions leading to myocardial fibrosis and remodeling. The development of Chronic Chagas Cardiomyopathy (CCC) in some patients while others remain asymptomatic is not fully understood, but dysregulated inflammatory resp...

2024-01-11 | MTBLS8390 | MetaboLights

Bile acid dehydroxylation by the gut microbiome

A metabolic pathway for bile acid dehydroxylation by the gut microbiome

ORGANISM(S): Clostridium (ncbitaxon:1485)

2020-03-02 | MSV000085048 | MassIVE

GNPS - Bile acid dehydroxylation by the gut microbiome

A metabolic pathway for bile acid dehydroxylation by the gut microbiome

ORGANISM(S): Clostridium (ncbitaxon:1485)

2020-03-02 | MSV000085048 | GNPS

The multikinase inhibitor Sorafenib targets mitochondria and synergizes with glycolysis blockade for cancer cell killing.

Objective: identify novel and relevant aspects of Sorafenib action on liver cancer cells. We found that in rat hepatocholangiocarcinoma (LCSC-2) cells, exposure to the MEK/multikinase inhibitor sorafenib did not inhibit ERK phosphorylation nor induced appreciable cell death in the low micromolar ra...

ORGANISM(S): Rattus norvegicus

2015-02-04 | E-GEOD-43053 | biostudies-arrayexpress

The National Lung Screening Trial: overview and study design.

Not available

S-EPMC3009383 | biostudies-literature

Reduced lung-cancer mortality with low-dose computed tomographic screening.

Not available

S-EPMC4356534 | biostudies-literature

Results of the two incidence screenings in the National Lung Screening Trial.

Not available

S-EPMC4307922 | biostudies-literature

Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis.