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Hibernomas are benign tumors with morphological features resembling brown fat. They consistently display cytogenetic rearrangements, typically translocations, involving chromosome band 11q13. Here we demonstrate that these aberrations are associated with concomitant deletions of AIP and MEN1, tumor ...
ORGANISM(S): Homo sapiens 
Comparison of transcriptome in adult control F344 kidneys versus Hsd11b2 knockout kidneys (model of syndrome of apparent mineralocorticoid excess; SAME)
ORGANISM(S): Rattus norvegicus 
Activation of the pregnane X receptor (NR1I2) by drugs and other xenobiotics stimulates (or suppresses) expression of numerous genes involved in the metabolic elimination of foreign compounds and some toxic endogenous substrates. We used microarray analysis to identify genes whose expression in rat ...
ORGANISM(S): Rattus norvegicus 
Bats play a critical role in controlling agricultural pests, yet foraging in croplands exposes them to hazardous pesticides. These chemicals pose significant risks for bats by impairing immune function, locomotion, and cognition even at low doses, jeopardizing their survival and ecological role. Her...
ORGANISM(S): Eptesicus Fuscus 
IFN-gamma is a classical microglial stimulant. We used microarrays to investigate the microglial gene regulatory network activated by interferon-gamma. Experiment Overall Design: Primary rat microglia cultures were established and maintained for 15 days. For activation studies, fresh media containi...
ORGANISM(S): Rattus norvegicus 
The well-defined battery of in vitro systems applied within chemical cancer risk assessment is often characterised by a high false-positive rate, thus repeatedly failing to correctly predict the in vivo genotoxic and carcinogenic properties of test compounds. Toxicogenomics, i.e. mRNA-profiling, has...
ORGANISM(S): Mus musculus 
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