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TranscriptomicsRemodeling of Brown and White Adipose Tissue by NT-PGC-1α-Mediated Gene Regulation
The β-adrenergic receptor signaling pathway is a major component of adaptive thermogenesis in brown and white adipose tissue during cold acclimation. The β-AR activation highly induces transcriptional coactivator PGC-1α and its splice variant N-terminal (NT)-PGC-1α, promoting the transcription progr...
ORGANISM(S): Mus musculus 
2015-08-07 | E-GEOD-71774 | biostudies-arrayexpress
TranscriptomicsAdipose subtype-selective recruitment of TLE3 in thermogenic gene programs
Transcriptional effectors of white adipocyte-selective gene expression have not been described. TLE3 is a white-selective cofactor that acts reciprocally with the brown-selective cofactor Prdm16 to specify lipid storage and thermogenic gene programs. When expressed at elevated levels in brown fat, T...
ORGANISM(S): Mus musculus 
2013-09-27 | E-GEOD-51223 | biostudies-arrayexpress
TranscriptomicsTopoisomerase function in E. coli replication fork movement
Analysis of topoisomerase function in bacterial replication fork movement: use of DNA microarrays. We used DNA microarrays of the Escherichia coli genome to trace the progression of chromosomal replication forks in synchronized cells. We found that both DNA gyrase and topoisomerase IV (topo IV) prom...
ORGANISM(S): Escherichia coli 
2001-07-30 | E-GEOD-8 | biostudies-arrayexpress
TranscriptomicsHuman subcutaneous adipose tissue gene expression (SOS Sib-pair study, offspring cohort)
Obesity has considerable effects on morbidity and mortality, and the prevalence of obesity has been increasing rapidly worldwide during the past two decades. Even if obesity affects the entire individual, adipose tissue plays a central role in the development of obesity. Expression profiling of adip...
ORGANISM(S): Homo sapiens 
2013-01-22 | E-GEOD-27916 | biostudies-arrayexpress
TranscriptomicsAnalysis of gene expression signatures in brown adipose tissue (BAT) following acute activation of AgRP neurons
We have found that acute activation of AgRP-neurons lead to inhibition of insulin-stimulated glucose uptake into BAT. Based on this finding, we asked whether this effect was accompanied by acute changes in gene expression, which could point to the mechanism(s) underlying the impaired insulin sensiti...
ORGANISM(S): Mus musculus 
2016-02-10 | E-GEOD-77766 | biostudies-arrayexpress
TranscriptomicsHuman s.c adipose tissue gene expression during diet-induced weight loss
Obesity has considerable effects on morbidity and mortality and the prevalence of obesity has been increasing rapidly worldwide during the past two decades. Even if obesity affects the entire individual, adipose tissue play a central role in the development of obesity. Expression profiling of adipos...
ORGANISM(S): Homo sapiens 
2013-01-22 | E-GEOD-35710 | biostudies-arrayexpress
TranscriptomicsDevelopment pathway for skin resident memory CD103+CD8+ T cells
Tissue resident memory T cells (TRM) provide superior protection against infection localised to extra-lymphoid compartments in the body. Here we show that CD103+CD8+ TRM cells develop in skin from killer cell lectin-like receptor (KLR)G1-negative precursors that selectively infiltrate the epithelia...
ORGANISM(S): Mus musculus 
2013-10-01 | E-GEOD-47045 | biostudies-arrayexpress
TranscriptomicsGenomewide demarcation of RNA PolII transcription units by physical fractionation of chromatin- Neutral enrichment
Epigenetic modifications of chromatin serve an important role in regulating the expression and accessibility of genomic DNA. We report here a genomewide approach for fractionating yeast chromatin into two functionally distinct parts, one containing RNA polymerase II transcribed sequences, and the ot...
ORGANISM(S): Saccharomyces cerevisiae 
2010-07-01 | E-GEOD-5651 | biostudies-arrayexpress
TranscriptomicsImpact of Animal Strain on Gene Expression in a Rat Model of Acute Cardiac Rejection
The expression levels of many genes show wide natural variation among strains or populations. This study investigated the potential for animal strain-related genotypic differences to confound gene expression profiles in acute cellular rejection (ACR). Additional analysis allowed for selection of 49 ...
ORGANISM(S): Rattus norvegicus 
2010-05-01 | E-GEOD-6342 | biostudies-arrayexpress
TranscriptomicsGenomewide demarcation of RNA PolII transcription units by physical fractionation of chromatin- ORF enrichment
Epigenetic modifications of chromatin serve an important role in regulating the expression and accessibility of genomic DNA. We report here a genomewide approach for fractionating yeast chromatin into two functionally distinct parts, one containing RNA polymerase II transcribed sequences, and the ot...
ORGANISM(S): Saccharomyces cerevisiae 
2006-08-30 | E-GEOD-5649 | biostudies-arrayexpress
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