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MetabolomicsPeripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
TranscriptomicsTranscription profiling of 5 strains of rat: WKY, spontaneously hypertensive rat (SHR) and 3 reciprocal congenic strains (WconSA, SconSA and SISA)
5 strains of rat, WKY, spontaneously hypertensive rat (SHR) and 3 reciprocal congenic strains (WconSA, SconSA and SISA) were used to generate expression data across the genome using the Affymetrix rat genome chip set comprising the 230 A and 230 B chips. 5 animals from each strain were used. Express...
ORGANISM(S): Rattus norvegicus 
2007-04-16 | E-TABM-45 | biostudies-arrayexpress
TranscriptomicsMitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling
Transcriptome from immortalized murine brown adipocytes BMC. Cells were transfected with siRNA construct #1 or construct #2 (pool) or non-targeting control on day 3 of differentiation and harvested on day 7 of differentiation.
ORGANISM(S): Mus musculus 
2026-09-23 | E-MTAB-17577 | biostudies-arrayexpress
TranscriptomicsDigital gene expression tag profiling of digit morphologies in bats
As the only truly flying mammals, bats use their unique wing formed from elongated digits connected by membranes to power their flight. The forelimb of bats consists of four elongated digits (digits II-V) and one shorter digit (digit I) that is morphologically similar to the hindlimb digits. Elongat...
ORGANISM(S): Myotis ricketti 
2010-12-06 | E-GEOD-20038 | biostudies-arrayexpress
ProteomicsA transient protein folding response targets aggregation in the early phase of TDP-43-mediated disease
Understanding the mechanisms that drive TDP-43 pathology is integral to combating amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Here we generated a longitudinal quantitative proteomic map of the cortex from the cytoplasmic TDP-43 rNLS8 mouse model of ALS and FTLD ...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-31 | PXD042382 | Pride
Ftld Longitudinal Als Cortex Mouse Proteinopathy Motor neuron disease Mnd Tdp-43 Lc-ms/ms Tandem mass tagging Amyotrophic lateral sclerosis Frontotemporal dementia Ftd Frontotemporal lobar degeneration 
TranscriptomicsCHD5, A Brain-Specific Chromatin Remodeling Enzyme, Regulates Expression Of Neuronal Genes.
CHD5 is frequently deleted in neuroblastoma, and appears to be a tumor suppressor gene; however, little is known about the role of CHD5. We found CHD5 mRNA was restricted to brain; by contrast most other remodeling ATPases were broadly expressed. CHD5 protein isolated from mouse brain was associat...
ORGANISM(S): Rattus norvegicus 
2011-09-21 | E-GEOD-27620 | biostudies-arrayexpress
UnknownThe Recent Increase in Invasive Bacterial Infections: A Report From the National COVID Cohort Collaborative.
Not available
S-EPMC11812670 | biostudies-literature
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